Cannabis Association With Sleep Study

NCT06982950 | Not Yet Recruiting

• 1 other identifier: IRB28366
• Study Type: interventional
• Target: 60
• Locations: 0 countries
• Sites: N/A

Brief Summary

The purpose of this study is to learn more about cannabis use, sleep, and stress, and whether there is any relationship between the three.

Conditions

Sleep

Keywords

Sleep, slow wave; Polysomnography; Marijuana Abuse; Cannabinoids; Ecological Momentary Assessment; Sleep Duration

Outcome Measures

Primary Outcomes (3)

• Daily Cannabis Use Frequency

  The number of smoking/vaping sessions per day.

  Assessed in surveys performed 4 times per day, and across the entire 21-day study

• Wake After Sleep Onset (WASO)

  Wake after sleep onset (measured in minutes) will be assessed each night from actigraphy; larger value indicates greater disruptions to sleep.

  21 days

• Cortisol Awakening Response

  Salivary cortisol levels assessed as the difference between waking and peak levels assessed \~30-45 minutes after awakening.

  8 nights

Secondary Outcomes (18)

• Wake After Sleep Onset (Polysomnography)

  8 nights

• Sleep Latency

  8 nights

• Total Sleep Time

  up to 21 days

• Sleep Macroarchitecture

  8 nights

• Sleep Microarchitecture

  8 nights

Study Arms (2)

Sleep Restriction

EXPERIMENTAL

After a baseline assessment of sleep, participants in this arm will undergo 2 nights of restricted sleep (4 hour time in bed).

Other: Manipulation of Sleep Duration

Sleep Extension

EXPERIMENTAL

After a baseline assessment of sleep, participants in this arm will undergo 3 nights of an extended sleep opportunity (10 hour time in bed).

Other: Manipulation of Sleep Duration

Interventions

Manipulation of Sleep Duration OTHER

After a baseline assessment of sleep, participants will undergo either 2 nights of restricted sleep (4 hour time in bed) followed by a recovery sleep, OR 3 nights of an extended sleep opportunity (10 hour time in bed)

Sleep Extension; Sleep Restriction

Eligibility Criteria

• Age: 21 Years - 29 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• fluent in English
• \<BMI\<40 kg/m2
• no shift work in the last 12 months
• no travel across time zones in the last 2 months.

You may not qualify if:

• Chronic disease-Medical history/prior diagnosis of the following:
• cardiometabolic disease (e.g., myocardial infarction, angina, diabetes)
• essential hypertension
• hepatic impairment
• severe obstructive sleep apnea
• restless legs syndrome
• parasomnia
• neurological disease (e.g., early onset dementia)
• unstable psychiatric disorders (e.g., bipolar disorder, schizophrenia, major depression with suicidality).
• Drug/Alcohol use criteria:
• Illicit drugs apart from cannabis or related products are prohibitive.
• Volunteers may consume caffeine, however, \>3 cups of coffee (or otherwise equivalent of \>300mg/day) is prohibitive.
• Participants who consume \>14 alcoholic drinks/week and/or have a diagnosis (or history) of alcohol use disorder will be excluded (a toxicological urine screen will be conducted to verify reported non-use during the initial screening and on the day of admission to the in-laboratory portion of the study).
• Contraceptives are required for women and will continue to be taken throughout the experiment.
• Prior Shift Work:

Sponsors & Collaborators

• Oregon Health and Science University: lead

MeSH Terms

Conditions

Marijuana Abuse

Condition Hierarchy (Ancestors)

Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Central Study Contacts

Nicole Bowles, PhD

CONTACT

5034942541; circadian@ohsu.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Assitant Professor

Model Details: After a baseline assessment of sleep, participants will undergo either 2 nights of restricted sleep (4h time in bed \[TIB\]) followed by a recovery sleep, OR 3 nights of an extended sleep opportunity (10h TIB)

Study Record Dates

• First Submitted: May 3, 2025
• First Posted: May 21, 2025
• Study Start: July 1, 2025
• Primary Completion (Estimated): June 30, 2030
• Study Completion (Estimated): June 30, 2032
• Last Updated: May 21, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share