Glycemic Control Following Occupational Work in a Hot Environment

NCT06982612 | Not Yet Recruiting

• 1 other identifier: LEON21544
• Study Type: interventional
• Target: 20
• Locations: 0 countries
• Sites: N/A

Brief Summary

Occupational workers regularly perform physically demanding tasks in hot environments, exposing them to heat stress and potential dehydration. While the physiological impacts of heat exposure are well-documented, its effects on glycemic control remain less understood. Given the rising global temperatures due to climate change and the increasing prevalence of metabolic disorders such as obesity and type 2 diabetes, it is essential to investigate how heat exposure during work influences glycemic regulation. Understanding these interactions will help inform future occupational health guidelines and metabolic health recommendations in physically demanding industries.

Conditions

Plasma Glucose Following Prolonged Heat Exposure

Keywords

heat; plasma glucose; worker; glycemia; OGTT

Outcome Measures

Primary Outcomes (1)

• Plasma glucose

  Measured using colorimetric assay from venous blood samples

  8hours

Secondary Outcomes (12)

• Plasma insulin

  8hours

• Plasma osmolality

  8hours

• Plasma volume change

  8hours

• Urine volume

  8hours

• Body mass

  8hours

Other Outcomes (3)

• N-back task for working memory (cognitive function)

  8hours

• Go/no-go task for response inhibition (cognitive function)

  8hours

• Stroop test

  8hours

Study Arms (2)

Hot condition

EXPERIMENTAL

Light exercise in a hot environment with ad libitum water intake

Other: Hot environment

Temperate condition

EXPERIMENTAL

Light exercise in a temperate environment with ad libitum water intake

Other: Temperate condition

Interventions

Hot environment OTHER

Participants exercising in a 36 degrees celsius environment

Hot condition

Temperate condition OTHER

Participants exercising in a 18 degrees celsius environment

Temperate condition

Eligibility Criteria

• Age: 18 Years - 45 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• Male or female
• Generally fit and healthy
• Participate in endurance or intermittent exercise at least 3 times a week or minimum of 150 minutes moderate intensity activity per week

You may not qualify if:

• Under 18 or 45 and over,
• any morbidity or medication that might influence carbohydrate/fat metabolism (i.e., liver/renal/cardiovascular disease) or cycling ability (musculoskeletal injury etc),
• coagulation or bleeding disorders,
• blood-borne illness,
• heart conditions,
• congenital heart disease,
• uncontrolled exercise-induced asthma,
• smoking (including vaping),
• allergies to the products used in the study,
• dieting or restrained eating behaviours.

Sponsors & Collaborators

• Loughborough University: lead

Central Study Contacts

Stephen A Mears, PhD

CONTACT

+44 1509 226391; s.a.mears@lboro.ac.uk

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: BASIC SCIENCE
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Dr - Senior lecturer

Model Details: Randomised, crossover design

Study Record Dates

• First Submitted: May 1, 2025
• First Posted: May 21, 2025
• Study Start: May 1, 2025
• Primary Completion: May 1, 2026
• Study Completion (Estimated): October 1, 2026
• Last Updated: May 21, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will not share