The Proposed Study Aims to Investigate the Efficacy of Quercetin as an Adjunctive to Mechanical Debridement in Treatment of Periodontitis

NCT06982248 | Active Not Recruiting Phase 2 FDA Drug

• 1 other identifier: A03030240H
• Study Type: interventional
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients

Conditions

Periodontal Pocket

Outcome Measures

Primary Outcomes (1)

• assessment clinical attachment level by UNC 15 periodontal probe

  12 weeks

Secondary Outcomes (1)

• assessment of the gingival crevicular levels of NF-κB by Elisa kit

  12 weeks

Study Arms (4)

Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin

EXPERIMENTAL

selected patients receive SRP and chitosan nanoparticles gel loaded by quercetin

Drug: NSP and chitosan nanoparticles gel loaded by quercetin

Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel.

EXPERIMENTAL

selected patients receive SRP and chitosan nanoparticles gel

Drug: NSP and chitosan nanoparticles gel

Group 3: Periodontitis patients treated by NSPT only

ACTIVE COMPARATOR

NSPT

Procedure: scaling and root planning

Group 4: Periodontally healthy subjects.

NO INTERVENTION

healthy individual act as control group

Interventions

NSP and chitosan nanoparticles gel loaded by quercetin DRUG

NSP and chitosan nanoparticles gel loaded by quercetin

Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin

NSP and chitosan nanoparticles gel DRUG

NSP and chitosan nanoparticles gel

Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel.

scaling and root planning PROCEDURE

NSPT

Group 3: Periodontitis patients treated by NSPT only

Eligibility Criteria

• Age: 25 Years - 55 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)

You may qualify if:

• \- Patients of both sexes with an age ranging between 25 and 55 years will be included in the study. Patients diagnosed as having periodontitis based on clinical and radiographic examinations will be included

You may not qualify if:

• Insulin dependent diabetes
• Thyroid disease
• Patients with sensitivity to the medication used in the study
• patients with a history of antibiotic use or anti-inflammatory drugs during the previous 3 months prior to the study will be excluded from the study.
• Additionally, patients with systemic diseases, smokers, pregnant and lactating patients, and patients not compliant with oral hygiene procedures will also be excluded

Sponsors & Collaborators

• Mansoura University: lead

Study Sites (1)

Faculty of Dentistry, Mansoura University

Aga, Egypt

Location

MeSH Terms

Conditions

Periodontal Pocket

Interventions

Tooth Exfoliation

Condition Hierarchy (Ancestors)

Periodontitis; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases

Intervention Hierarchy (Ancestors)

Dental Physiological Phenomena; Digestive System and Oral Physiological Phenomena

Study Officials

• Jilan mohamed

  Mansoura University

  STUDY DIRECTOR

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: FACTORIAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin. Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel. Group 3: Periodontitis patients treated by NSPT only. Group 4: Periodontally healthy subjects.

Study Record Dates

• First Submitted: December 11, 2024
• First Posted: May 21, 2025
• Study Start: August 15, 2024
• Primary Completion: February 1, 2025
• Study Completion: June 1, 2025
• Last Updated: May 21, 2025

Record last verified: 2025-05

Locations

EG (1)