Modeling Clinical Outcomes in Gambling Addiction

NCT06981546 | Not Yet Recruiting

• 2 other identifiers: 69HCL21_02702024-A01805-42
• Study Type: observational
• Target: 268
• Locations: 1 country
• Sites: 9

Brief Summary

Gambling disorder (GD) is recognized as an addictive disorder. Financial consequences of GD are often dramatic, inducing professional, familial, legal and medical repercussions and particularly mental health consequences. MOGADOR is a longitudinal, multicentric, prospective, prognostic study, which aims to identify factors predicting the evolution of french patients with GD in care centers particularly involved in the management of GD. The main goal will focus on evolution of DSM-5 (Diagnostic and Statistical Manual of Mental Disorder 5th edition) GD criteria during the first year of follow-up. The prognostic factors will be collected at base-line and they will be considered to influence the long-term prognosis of patients. For patients suffering of GD, our main hypothesis is that initial factors like individual socio-demographic characteristics, clinical psychiatric profiles, addiction comorbidities, and behaviour are associated with the clinical prognosis (total remission of DSM-5 criteria of GD at 12 months). MOGADOR will be the first study, aiming to model prognostic aspects of GB in populations specially monitored for this disorder.

Conditions

Gambling Disorder

Keywords

Gambling disorders; Modeling outcomes; Socio-demographic Characteristics; Clinical psychiatric profiles

Outcome Measures

Primary Outcomes (2)

• Partial remission of gambling disorder at 12 months (strictly less than 4 DSM-5 criteria)

  Assessment of DSM-5 criteria will be performed by the clinician, and by a previously trained CRA if clinical follow-up is discontinued.

  DSM-5 criteria assessment will be conducted at 9 and 12 months after inclusion.

• modeling prognostic factors

  The prognostic factors, studied will be: number of initial DSM-5 criteria, gender, age, marital status, housing, employment status, socioeconomic level, time spent gambling, impulsivity, type of gambling, location of gambling, and also the factor with the strongest association in univariate analysis among the following factors: * Depression (PHQ scale), * Anxiety (GAD scale), * Quality of life (SF-36 scale).

  at inclusion visit.

Study Arms (1)

Patients with gambling disorder

OGADOR will focus exclusively on patients with DSM-5 criteria for gambling disorder and on demand for medical care. In this study psychiatric and addictological comorbidities, frequent in such a cohort, will constitute a specific inclusion factor, key characteristic leading an analysis of the impact on the patient prognosis.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

268 patients with gambling disorder according to DSM-5 criteria newly managed in one of the participating centers or who had an interruption in management of more than 6 months.

You may qualify if:

• Patient, male or female, over 18 years old, consulting in one of the participating centers.
• First treatment for gambling disorder or no treatment in the last 6 months (initiation or re-initiation of care).

You may not qualify if:

• Unable to be reached by phone.
• Unable to use the internet.
• Patient under antiparkinsonian treatment of the dopaminergic family.
• Being treated with a drug that may trigger/increase symptoms of gambling disorder (e.g. dopamine agonist).
• Subject under guardianship.

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (9)

Hôpital Jen Minjoz, CHU de Besançon

Besançon, 25030, France

Location

Service Universitaire d'Addictologie de Lyon (SUAL), CH Le Vinatier

Bron, 69500, France

Location

Service Universitaire d'Addictologie de Lyon (SUAL), Groupement Hospitalier Est

Bron, 69500, France

Location

Service Universitaire d'Addictologie, CHU de Clermont-Ferrand

Clermont-Ferrand, 63000, France

Location

Name of location * Service d'Addictologie, Groupe Hospitalier Seclin Carvin

Lille, 59000, France

Location

Centre Expert Régional du Jeu Pathologique (CERJeP Limousin)

Limoges, 87000, France

Location

Service Universitaire d'Addictologie, CHU de Nîmes

Nîmes, 30000, France

Location

Assistance Publique des Hôpitaux de Paris, Hôpital Marmottan

Paris, 75017, France

Location

Hôpital de Bellevue, CHU de St-Etienne

Saint-Etienne, 42000, France

Location

MeSH Terms

Conditions

Gambling

Condition Hierarchy (Ancestors)

Risk-Taking; Behavior; Disruptive, Impulse Control, and Conduct Disorders; Mental Disorders

Central Study Contacts

Véronique FONTEILLE, MD, PhD

CONTACT

04 72 11 80 64; veronique.fonteille@chu-lyon.fr

Pauline DROUIN

CONTACT

pauline.drouin@chu-lyon.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 5, 2025
• First Posted: May 20, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): September 1, 2029
• Study Completion (Estimated): September 1, 2030
• Last Updated: May 20, 2025

Record last verified: 2025-05

Locations

FR (9)