Atrial Fibrillation Recurrence Prediction

NCT06977516 | Completed

• 1 other identifier: KY-2025-068
• Study Type: observational
• Target: 2,508
• Locations: 1 country
• Sites: 5

Brief Summary

We aimed to develop an dual-branch deep learning network that integrates feature representations extracted from medical texts using large language models, with structured data features derived from perioperative records of AF ablation patients. This integrated approach provides novel clinical insights into risk prognosis and enhances strategies for post-procedural management in AF ablation.

Conditions

Atrial Fibrillation Recurrence

Keywords

Atrial Fibrillation Recurrence; Large Language Model; Deep Learning; Catheter Ablation

Outcome Measures

Primary Outcomes (1)

• Late Atrial Fibrillation Recurrence

  Recurrence occurring after 3 months are considered late recurrences.

Secondary Outcomes (1)

• Early Atrial Fibrillation Recurrence

  Recurrences occurring within 3 months postoperatively are classified as early recurrences.

Study Arms (2)

Atrial Fibrillation Recurrence

According to the latest ACC/AHA guidelines, AF recurrence is defined as the occurrence of atrial arrhythmias (atrial tachycardia, atrial flutter, or atrial fibrillation) lasting longer than 30 s following the procedure. Recurrences occurring within 3 months postoperatively are classified as early recurrences, while those occurring after 3 months are considered late recurrences.

Non Atrial Fibrillation Recurrence

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

We plan to extract data from patients diagnosed with atrial fibrillation who underwent their first atrial fibrillation ablation at the Fourth Affiliated Hospital of Zhejiang University School of Medicine, Taizhou Hospital of Zhejiang Province, the Affiliated Hospital of Yunnan University, Jinhua People's Hospital, and Beilun District Hospital. The collected data will include the patient's general information, laboratory tests, preoperative dynamic electrocardiogram text modality, echocardiogram text modality, and surgical procedure. The primary observation endpoint will be atrial fibrillation recurrence (defined as the detection of a persistent atrial arrhythmia lasting more than 30 seconds on ECG or dynamic ECG after ablation), with a follow-up period extending until March 2025.

You may not qualify if:

• Repeat ablation procedures;
• Valvular AF or AF with NYHA class IV heart failure.
• Missing Holter ECG or preoperative echocardiography data;
• Loss to follow-up after ablation;

Sponsors & Collaborators

• Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University: collaborator
• The Affiliated Hospital of Yunnan University: collaborator
• Jinhua People's Hospital: collaborator
• Beilun District People's Hospital: collaborator
• The Fourth Affiliated Hospital of Zhejiang University School of Medicine: lead

Study Sites (5)

The Affiliated Hospital of Yunnan University

Kunming, Yunnan, 650000, China

Location

Jinhua People's Hospital

Jinhua, Zhejiang, 321000, China

Location

Beilun District People's Hospital

Ningbo, Zhejiang, 315800, China

Location

Taizhou Hospital of Zhejiang Province affiliated to Wenzhou Medical University

Taizhou, Zhejiang, 317000, China

Location

The Fourth Affiliated Hospital of Zhejiang University School of Medicine

Yiwu, Zhejiang, 322000, China

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: May 11, 2025
• First Posted: May 18, 2025
• Study Start: April 15, 2025
• Primary Completion: June 30, 2025
• Study Completion: August 31, 2025
• Last Updated: March 12, 2026

Record last verified: 2026-03

Locations

CN (5)