Association of C-reactive Protein-albumin-lymphocyte Index (CALLY) With All-cause Mortality in Diabetic Patients

NCT06976359 | Completed

• 2 other identifiers: 20250508CALLYThe 14th Five-Year Plan Yunnan
• Study Type: observational
• Target: 3,988
• Locations: 1 country
• Sites: 1

Brief Summary

Based on retrospective cohort data from 3,988 diabetic patients in the NHANES database, this study is the first to show a significant negative correlation between the CALLY index and all-cause mortality in diabetic patients, with good predictive ability for their survival risk. Our findings can help clinicians better assess disease progression in diabetic patients and provide a reference for personalized, precision medicine.

Conditions

Diabetes

Keywords

Diabetes

Outcome Measures

Primary Outcomes (1)

• mortality

  all-cause mortality

  2025-5-8

Eligibility Criteria

• Age: 40 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

This study included 3,988 participants, with 1,821 deaths (weighted mortality rate: 41.7%) during a median follow-up of 131 months. Table 1 shows the baseline characteristics of participants, stratified by final mortality status. Compared to survivors, non-survivors were older (68.34 vs. 57.26 years), had a higher proportion of males (52.70% vs. 49.34%), lower educational attainment (38.15% vs. 24.50%), and higher rates of comorbid hypertension (69.44% vs. 60.50%) and cardiovascular disease (42.34% vs. 15.50%). Non-survivors also had a lower ln CALLY index (0.82 vs. 1.02, p = 0.0006). Other differences are shown in Table 1.

You may qualify if:

• (1) self-reported doctor-diagnosed diabetes; (2) fasting blood glucose ≥ 7.0 mmol/L; (3) two-hour oral glucose tolerance test blood glucose ≥ 11.1 mmol/L; (4) glycated hemoglobin A1c (HbA1c) ≥ 6.5%; or (5) use of hypoglycemic medication.

Sponsors & Collaborators

• Kunming Children's Hospital: lead

Study Sites (1)

Kunming Children's Hospital

Kunming, Yunnan, 650000, China

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

HDL, TC, BUN,SCR

MeSH Terms

Conditions

Diabetes Mellitus

Condition Hierarchy (Ancestors)

Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: clinician

Study Record Dates

• First Submitted: May 8, 2025
• First Posted: May 16, 2025
• Study Start: April 8, 2025
• Primary Completion: May 8, 2025
• Study Completion: May 8, 2025
• Last Updated: May 16, 2025

Record last verified: 2025-05

Locations

CN (1)