A Phase I Study to Evaluate the PK and PD Profiles of GZR102 Injection Versus GZR4 Injection and GZR18 Injection Given Separately in Chinese Adult Overweight Subjects

NCT06974487 | Not Yet Recruiting Phase 1

• 1 other identifier: GZR102-T2D-101
• Study Type: interventional
• Target: 30
• Locations: 1 country
• Sites: 1

Brief Summary

This trial is a randomized, double-blind, three-period crossover Phase I Clinical Study conducted in Chinese adult overweight subjects to evaluate the safety, tolerability, PK and PD profiles of a single dose of GZR102 injection versus GZR4 injection and GZR18 injection given separately. Subjects undergo a screening phase of up to 3 weeks (D-21 to D-3). Eligible subjects are randomized in a 1:1:1:1:1:1 ratio into six dosing sequences, receiving single doses of GZR102 injection, GZR4 injection, and GZR18 injection across 3 cycles. A washout period of at least 1 week separates each cycle.

Conditions

Type 2 Diabetes

Outcome Measures

Primary Outcomes (1)

• AUC0-t

  Area under the plasma concentration-time curve at 0 h to last observation time-point after a single dose.

  Day 36 (end of period)

Secondary Outcomes (5)

• AUC0-inf

  Day 36 (end of period)

• TEAEs

  Day 36 (end of period)

• Hypoglycemia

  Day 36 (end of period)

• Immunogenicity

  Day 36 (end of period)

• Cmax

  Day 36 (end of period)

Study Arms (3)

GZR102 injection

EXPERIMENTAL

Participants will get a single dose of GZR102 injection （fixed-ratio combination of GZR4 and GZR18）.

Drug: GZR102 injection

GZR4 injection

ACTIVE COMPARATOR

Participants will get a single dose of GZR4 injection

Drug: GZR18 injection

GZR18 injection

ACTIVE COMPARATOR

Participants will get a single dose of GZR18 injection

Drug: GZR4 injection

Interventions

GZR102 injection DRUG

Participants will get a single dose of GZR102 injection （fixed-ratio combination of GZR4 and GZR18）.

GZR102 injection

GZR4 injection DRUG

Participants will get a single dose of GZR4 injection

GZR18 injection

GZR18 injection DRUG

Participants will get a single dose of GZR18 injection

GZR4 injection

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)

You may qualify if:

• \. Subjects sign the Informed Consent Form (ICF) before the study, fully understand the contents, process and possible adverse reactions of the study, and be able to follow the contraindications and restrictions specified in this protocol.
• \. Subjects (male or female) age 18-60 years old (inclusive) at the time of signing ICF.
• \. Body weight ≥ 60 kg, body mass index (BMI) ≥ 24 kg/m2 and \< 28 kg/m2 at screening.
• \. No birth plan from the signing of ICF to 8 weeks after the last dose, willingness to use effective methods of contraception, and no plan for sperm donation. Females of childbearing potential must not be lactating and must have negative results of blood pregnancy tests at screening and predose.

You may not qualify if:

• \. History of drug abuse prior to screening; or positive results for drug abuse at screening.
• \. History of alcohol abuse defined as an average alcohol intake of more than 14 units per week (1 standard unit = 360 mL of beer or 150 mL of 12% wine or 45 mL of 40% spirits) within 6 months prior to screening.
• \. Subjects who smoked \> 5 cigarettes/day within 3 months prior to screening or who cannot stop using any tobacco products during the study.
• \. Subjects with a history of allergy to ≥ 2 drugs, or known hypersensitivity or intolerance to the IMP or similar products and their excipients.
• \. Presence of any suspected and/or definitively diagnosed malignancy at screening; or patients diagnosed with other malignancies within 5 years; 6. Previous or current medical history of cardiovascular, hematological, respiratory, digestive, urinary, endocrine/metabolic, neurological, or psychiatric disorders that, in the investigator's judgment, may affect the study outcomes.
• \. History of acute or chronic pancreatitis, biliary/gallbladder diseases , or pancreatic injury.
• \. Major surgery (including but not limited to procedures requiring general anesthesia) within 3 months prior to screening; or history of organ transplantation (except corneal transplantation performed more than 4 months prior to screening); or incomplete recovery from illness, trauma, or surgery at screening (e.g., significant impairment in daily living or working capacity compared to pre-illness/injury/surgery status); or planned surgery during the study period.
• \. Blood donation or significant blood loss (\> 400 mL), or blood transfusion in the 3 months prior to screening.
• \. Presence of any clinically significant abnormalities in 12-lead electrocardiogram, vital signs (blood pressure, respiration, pulse rate, body temperature), physical examination, imaging examination, or laboratory tests (hematology, urinalysis, blood chemistry, coagulation function, serum amylase, serum lipase, calcitonin) as determined by the investigator at screening..
• \. Positive screening results for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, human immunodeficiency virus (HIV) antibody, or treponema pallidum antibody infection at screening.
• \. History of organ transplantation, or acquired or congenital immune system disorders.
• \. Participation in a clinical study of another investigational medicinal product (IMP), surgery, or device within 3 months before screening, or within 5 half-lives of the previous IMP (whichever is longer). Or plan to participate in another clinical study of an IMP, surgery, or device before completing all scheduled assessments in the clinical study.
• \. Subjects who have used GLP-1 receptor agonists or drugs with the mechanism of action of GLP-1R agonists.
• \. Subjects who are allergic to any food or have specific dietary requirements and cannot adhere to a standardized diet.
• \. History of needle or blood phobia, or difficulty with blood collection; or inability/unwillingness to undergo repeated venipuncture.

Sponsors & Collaborators

• Gan & Lee Pharmaceuticals.: lead

Study Sites (1)

Study site 01

Beijing, China

Location

MeSH Terms

Conditions

Diabetes Mellitus, Type 2

Condition Hierarchy (Ancestors)

Diabetes Mellitus; Glucose Metabolism Disorders; Metabolic Diseases; Nutritional and Metabolic Diseases; Endocrine System Diseases

Central Study Contacts

xuepeng Chen

CONTACT

010-56456739; xuepeng.chen@ganlee.com

Study Design

• Study Type: interventional
• Phase: phase 1
• Allocation: RANDOMIZED
• Masking: QUADRUPLE
• Who Masked: PARTICIPANT, CARE PROVIDER, INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 28, 2025
• First Posted: May 16, 2025
• Study Start: May 8, 2025
• Primary Completion: September 30, 2025
• Study Completion: September 30, 2025
• Last Updated: May 16, 2025

Record last verified: 2025-04

Locations

CN (1)