NCT06972147

Brief Summary

A new clinical entity of eosinophilic esophagitis, Food Induced Immediate Response of the Esophagus or FIRE, has been described since 2020. Diagnostic criteria are not clearly established. Specific questioning is necessary for differential diagnosis, such as the oro-pharyngeal syndrome notably described in pollinics, or a mechanical blockage strictly speaking linked to esophagitis. The aim is to obtain epidemiological data on this entity.

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
40

participants targeted

Target at P25-P50 for all trials

Timeline
Completed

Started Jul 2025

Shorter than P25 for all trials

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

First Submitted

Initial submission to the registry

March 14, 2025

Completed
2 months until next milestone

First Posted

Study publicly available on registry

May 14, 2025

Completed
2 months until next milestone

Study Start

First participant enrolled

July 1, 2025

Completed
10 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

May 1, 2026

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

May 1, 2026

Completed
Last Updated

December 24, 2025

Status Verified

October 1, 2025

Enrollment Period

10 months

First QC Date

March 14, 2025

Last Update Submit

December 23, 2025

Conditions

Eosinophilic Esophagitis

Outcome Measures

Primary Outcomes (1)

  • diagnosis of FIRE syndrome

    symptoms such as pain, pressure, choking or narrowing, in the oesophagus or retrosternum, within 10 minutes of ingestion, lasting a maximum of 120 minutes, when a specific food is ingested

    day 1

Study Arms (1)

eosinophilic esophagitis

questionnary

Eligibility Criteria

Age6 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)
Sampling MethodNon-Probability Sample
Study Population

Patient follow-up in the allergology unit of Angers University Hospital

You may qualify if:

  • Follow-up in the allergology unit of Angers University Hospital for eosinophilic esophagitis

You may not qualify if:

  • Patients or legal representative with severe communication or language comprehension difficulties
  • Patients or legal representatives objecting to study participation

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

HOPPE Anne

Angers, France

RECRUITING

CHU Lille

Lille, France

NOT YET RECRUITING

MeSH Terms

Conditions

Eosinophilic Esophagitis

Condition Hierarchy (Ancestors)

EsophagitisEsophageal DiseasesGastrointestinal DiseasesDigestive System DiseasesGastroenteritisEosinophiliaLeukocyte DisordersHematologic DiseasesHemic and Lymphatic DiseasesHypersensitivity, ImmediateHypersensitivityImmune System Diseases

Study Officials

  • Anne HOPPE

    University Hospital of Angers

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Anne HOPPE, MD

CONTACT

241353637anne.hoppe@chu-angers.fr

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
PROSPECTIVE
Target Duration
1 Day
Sponsor Type
OTHER GOV
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 14, 2025

First Posted

May 14, 2025

Study Start

July 1, 2025

Primary Completion

May 1, 2026

Study Completion

May 1, 2026

Last Updated

December 24, 2025

Record last verified: 2025-10

Locations

FR(2)