Wash-in Period in Patients Undergoing Low Flow Anesthesia

NCT06967948 | Recruiting

• 1 other identifier: SUckun
• Study Type: observational
• Target: 40
• Locations: 1 country
• Sites: 3

Brief Summary

Volunteers above the age of 18 and below the age of 60 who agreed to participate in the study were not exposed to any interventional intervention other than those routinely applied to the patient during and after the administration of the clinical standard anesthesia protocol. The value indicating the brain's response to hypnotic substances, the vapor concentration in the lung alveoli and the minimum amount of anesthesia gas used will be recorded at certain times. The aim of the researchers in the study was to observe the effect of two different fresh gas flow rates on the amount and cost of waste gas released into the atmosphere.

Conditions

Inhalation Anesthesia

Outcome Measures

Primary Outcomes (11)

• Demographic data

  Demographic data such as age (years), height (cm), weight (kg) and gender (male/female) of the volunteer patients will be analyzed to see if they are similar for both study groups.

  preoperative

• Duration of surgery

  It will be examined whether the duration of surgery (minutes) is similar for volunteer patients

  During the period of operation (2-4 hours)

• Duration of anesthesia

  It will be examined whether the duration of anesthesia (minutes) is similar for volunteer patients

  During the period of operation (2-4 hours)

• Heart rate

  We will examine whether there is a difference in heart rate (beats/minute) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter in volunteer patients

  During the period of operation (2-4 hours)

• Systolic blood pressure

  The volunteer patients will be examined for differences in systolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter

  During the period of operation (2-4 hours)

• Diastolic blood pressure

  The volunteer patients will be examined for differences in diastolic blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter

  During the period of operation (2-4 hours)

• Mean blood pressure

  The volunteer patients will be examined for differences in mean blood pressure (mmHg) values recorded at 5-minute intervals in the first half hour and at 15-minute intervals thereafter

  During the period of operation (2-4 hours)

• Oxygen saturation

  We will examine whether there is a difference between the oxygen saturation (%) values measured at 5-minute intervals in the first half hour and then at 15-minute intervals in volunteer patients.

  During the period of operation (2-4 hours)

• Total inhaled gas consumption

  Total inhaled gas consumption (milliliter) at the end of anesthesia will be examined whether it is similar for volunteer patients.

  During the period of operation (2-4 hours)

• Minimum alveolar concentration (MAC)

  Minimum alveolar concentration (MAC) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.

  During the period of operation (2-4 hours)

• Bispectral index (BIS)

  Bispectral index (BIS) values are recorded at 1-minute intervals in the first 10 minutes at the onset of anesthesia, at 5-minute intervals between 10 minutes and half an hour, and at 15-minute intervals after half an hour and will be examined for differences between volunteers.

  During the period of operation (2-4 hours)

Study Arms (2)

1 lt/min

''Wash in period'' 1 lt/min fresh gas flow is used.

4 lt/min

''Wash in period'' 4 lt/min fresh gas flow is used.

Eligibility Criteria

• Age: 18 Years - 60 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Male or female Between 18-60 years of age ASA I-II risk group patients with general anesthesia Duration of surgery between 2 hours and 4 hours

You may qualify if:

• ASA I-II risk group patients Duration of surgery between 2 hours and 4 hours, cases with general anesthesia

You may not qualify if:

• Patient refusal to participate in the study
• Under 18 years old BMI\>40
• Patients receiving invasive mechanical ventilator support in the last 1 month
• Patients who have received chemotherapy or radiotherapy in the last 2 months
• Those with severe lung disease (COPD, asthma, pulmonary infection, bronchiectasis, previous need for non-invasive mechanical ventilation, oxygen therapy or steroid therapy for acute attack)
• Known severe pulmonary hypertension
• Smoke poisoning (carbon monoxide, cyanide poisoning)
• Alcohol or acetone poisoning
• Malignant hyperthermia
• Intracranial tumor
• Hemodynamic instability
• Shock
• Neuromuscular disease
• Pathologies causing increased intracranial and intraocular pressure
• Those with severe cardiac arrhythmias Those with -EF\<30

Sponsors & Collaborators

• Serkan Uckun: lead

Study Sites (3)

Balıkesir University Health Practice and Research Hospital Operating Room

Balıkesir, Turkey (Türkiye)

RECRUITING

Balıkesir University Health Practice and Research Hospital

Balıkesir, Turkey (Türkiye)

RECRUITING

Balıkesir University Health Practice and Research Hospital

Balıkesir, Turkey (Türkiye)

RECRUITING

Central Study Contacts

Serkan Uçkun, assistant professor

CONTACT

+90 535 370 11 64; serkanuckun@yahoo.com

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: assistant professor

Study Record Dates

• First Submitted: April 14, 2025
• First Posted: May 13, 2025
• Study Start: April 10, 2025
• Primary Completion: October 1, 2025
• Study Completion: December 1, 2025
• Last Updated: May 16, 2025

Record last verified: 2025-04

Locations

TU (3)