Respiratory Virus Infections in Acute Heart Failure

NCT06967441 | Recruiting

• 1 other identifier: SNUBH IRB NO: B-2412-941-302
• Study Type: observational
• Target: 360
• Locations: 1 country
• Sites: 3

Brief Summary

Patients admitted to the cardiology department with acute heart failure who have a nasopharyngeal respiratory virus PCR test performed within 72 hours of admission will be enrolled in the study cohort. The detection rate of respiratory viruses including influenza virus, RSV, and coronavirus will be analysed. The investigators will also look for seasonal changes in the frequency of respiratory viruses and differences in the clinical presentation of heart failure based on respiratory virus infection.

Conditions

Acute Heart Failure Syndrome

Keywords

acute heart failure; respiratory virus

Outcome Measures

Primary Outcomes (1)

• Respiratory virus PCR detection rate

  Respiratory virus PCR detection rate (especially RSV, influenza virus) in acute HF

  Within 3 days of admission

Secondary Outcomes (5)

• Days of hospitalization

  From admission to discharge during index hospitalization (upto 30 days)

• Rate of ICU care or ventilation

  From admission to discharge during index hospitalization (upto 30 days)

• In hospital mortality

  From admission to discharge during index hospitalization (upto 30 days)

• mortality

  12 month

• Rehospitalization

  12month

Eligibility Criteria

• Age: 19 Years+
• Sex: all
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients hospitalised with AHF at three healthcare facilities who had respiratory virus PCR testing performed

You may qualify if:

• Adult aged 19 years or older admitted to the cardiology department with acute heart failure
• NT-proBNP \>300 pg/mL
• Clinician judgement of possible respiratory viral infection (fever \>38 degrees or cough, respiratory symptoms such as sputum or consolidation on x-ray or CRP \>5 mg/dL)
• Patients who have a nasopharyngeal swab for respiratory virus PCR test performed within 72 hours of admission for any of the 3 reasons

You may not qualify if:

• Patients with a clear other cause of acute heart failure (ex. ACS, bradycardia requiring a pacemaker, uncontrolled tachycardia, uncontrolled severe hypertension (SBP \>180mmHg or DBP \>110mmHg), haemoglobin \<7g/dL or AHF precipitated by medication non-adherence)
• If the cause of pulmonary oedema is prominently attributed to exacerbation of CKD
• If there is a clear other source of infection that can explain the fever

Sponsors & Collaborators

• Minjae Yoon: lead
• Samsung Medical Center: collaborator
• Seoul St. Mary's Hospital: collaborator

Study Sites (3)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, 13620, South Korea

RECRUITING

Samsung medical center

Seoul, South Korea

RECRUITING

Seoul ST. Mary's Hospital

Seoul, South Korea

RECRUITING

Central Study Contacts

Minjae Yoon, MD

CONTACT

+82-10-6334-1917; minjae1677@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Assistant professor

Study Record Dates

• First Submitted: April 17, 2025
• First Posted: May 13, 2025
• Study Start: April 7, 2025
• Primary Completion (Estimated): December 31, 2028
• Study Completion (Estimated): December 31, 2028
• Last Updated: March 11, 2026

Record last verified: 2026-03

Data Sharing

• IPD Sharing: Will not share

Locations

KR (3)