Uric Acid Levels and Migraine in Children

NCT06966037 | Completed DMC

• 1 other identifier: Balikesir University
• Study Type: observational
• Target: 2
• Locations: 1 country
• Sites: 1

Brief Summary

Migraine is recognized as one of the most prevalent neurological disorders. The exact pathophysiological mechanisms underlying migraine have not yet been fully elucidated. The present study aims to compare serum uric acid levels between pediatric patients with migraine and a control group. Additionally, this study seeks to explore the potential relationship between migraine attack frequency and gender differences in pediatric patients

Conditions

Migraine in Children

Keywords

migraine; children; uric acid levels

Outcome Measures

Primary Outcomes (1)

• Evaluation of Uric Acid Levels in Pediatric Patients with Migraine

  Migraine represents a significant neurological condition affecting individuals across all age groups, with a reported prevalence of 7.7% among children and adolescents. According to the widely accepted neurogenic inflammation hypothesis, sterile inflammation occurs in the dura mater surrounding the brain as a result of neuropeptide release from perivascular trigeminal nerve endings, leading to sensitization of sensory neurons .Uric acid is known to function as a potent endogenous antioxidant and free radical scavenger within the human body. It has been suggested that uric acid exerts dual effects on the central nervous system, demonstrating both neuroprotective and neurotoxic properties depending on its concentration. Although uric acid may enhance antioxidant and anti-inflammatory responses at physiological concentrations, it has been suggested that excessively elevated serum uric acid levels may contribute to increased oxidative stress and subsequent neuronal damage. The primary ou

  01.08.2019 and 01.03.2024

Study Arms (1)

Comparison of Laboratory Parameters Between Groups

The present study aims to compare serum uric acid levels between pediatric patients with migraine and a control group

Eligibility Criteria

• Age: 6 Years - 18 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients diagnosed with migraine were included as the study group, while the control group consisted of patients who presented to the pediatric neurology clinic during the same period for neuromotor development follow-up examinations.

You may qualify if:

• Patients diagnosed with migraine

You may not qualify if:

• Cerebral palsy Non-migraine headache Epilepsy Multiple congenital anomalies Congenital metabolic diseases Control group

Sponsors & Collaborators

• Aysen Orman: lead

Study Sites (1)

Mersin University

Mersin, 33000, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Migraine Disorders

Condition Hierarchy (Ancestors)

Headache Disorders, Primary; Headache Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases

Study Design

• Study Type: observational
• Observational Model: CASE CONTROL
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR INVESTIGATOR
• PI Title: Mersin University

Study Record Dates

• First Submitted: April 24, 2025
• First Posted: May 11, 2025
• Study Start: August 1, 2019
• Primary Completion: January 1, 2025
• Study Completion: April 1, 2025
• Last Updated: May 11, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL

Locations

TU (1)