Acute Effect of Isometric Excercise on Pain Sensitivity in Adults With Chronic Low Back Pain

NCT06963658 | Recruiting DMC

• 1 other identifier: ISO-Ex 0011112222
• Study Type: interventional
• Target: 90
• Locations: 1 country
• Sites: 1

Brief Summary

Randomized control trial to examine the immediate effect of isometric exercise on pressure pain threshold (PPT) in adults with chronic low back pain. The secondary aim of this study was to investigate the acute effects of isometric exercise on clinical pain intensity.

Conditions

Chronic Low Back Pain (CLBP)

Keywords

pain sensitivity; isometric exercise; low back pain

Outcome Measures

Primary Outcomes (1)

• The primary outcome is pain sensitivity

  Pain sensitivity was assessed via pressure pain threshold (PPT) using a standard procedure. The PPT was assessed by a digital pressure algometer (Wagner digital force Ten FDX 25 with 1 cm 2 rubber tip).This instrument has been widely utilized in various studies and has been shown to be valid and reliable in assessing PPT among people with musculoskeletal pain. If post intervention PPT was higher than pre-intervention value, this indicated that pain sensitivity decreased, suggesting exercise induced hypoalgesia occurred. If post-intervention PPT was lower than pre-intervention PPT, this indicates that pain sensitivity increased, suggesting that exercise induced hyperalgesia occurred.

  pre- and immediately post-intervention

Secondary Outcomes (1)

• The secondary outcome is the pain intensity in the lower back

  pre- and immediately post-intervention

Study Arms (3)

Multiple repetition isometric wall squat

EXPERIMENTAL

Participants were directed to rest their backs against the wall with shoulder width apart and feet parallel, then descend until they achieve an angle of 100 degrees at knee joint. The knee joint angle was assessed using a goniometer placed on the lateral epicondyle of the knee, aligned with the femur, while the anchor arm was aligned with the lateral malleolus. They were instructed to maintain the isometric hold for up to three minutes, or until volitional fatigue was reached.with a 30-second rest period between each squat hold.

Other: Multiple repetition isometric wall squat

Multiple Isometric wall squat exercise + Double Leg Lower with Isometric Hold

EXPERIMENTAL

Participants were directed to rest their backs against the wall with shoulder width apart and feet parallel, then descend until they achieve an angle of 100 degrees at knee joint. The knee joint angle was assessed using a goniometer placed on the lateral epicondyle of the knee, aligned with the femur, while the anchor arm was aligned with the lateral malleolus. They were instructed to maintain the isometric hold for up to three minutes, or until volitional fatigue was reached.with a 30-second rest period between each squat hold. Immediately post 60 second rest, Determine the participant's maximum angle using the double leg lowering test from supine position let the participant with both legs straightened before lifting the posterior hip, lowering the legs to a specific angle. Turn on the stopwatch. Hold the position near--maximally, try to achieve on (IES=9/10) and hold for the longest duration. They should reach 4 minutes for 3 repetition with 30 seconds rest between repetition

Other: Multiple Isometric wall squat exercise + Double Leg Lower with Isometric Hold

Control quiet seated rest

EXPERIMENTAL

The CON group served as the control group and did not perform any exercise. Participants were instructed to sit quietly in a standard height stationary clinical room patient chair for the entire eight minutes.

Other: Control quiet seated rest

Interventions

Multiple repetition isometric wall squat OTHER

Participants were directed to rest their backs against the wall with shoulder width apart and feet parallel, then descend until they achieve an angle of 100 degrees at knee joint. The knee joint angle was assessed using a goniometer placed on the lateral epicondyle of the knee, aligned with the femur, while the anchor arm was aligned with the lateral malleolus. They were instructed to maintain the isometric hold for up to three minutes, or until volitional fatigue was reached.with a 30-second rest period between each squat hold.

Multiple repetition isometric wall squat

Multiple Isometric wall squat exercise + Double Leg Lower with Isometric Hold OTHER

Participants were directed to rest their backs against the wall with shoulder width apart and feet parallel, then descend until they achieve an angle of 100 degrees at knee joint. The knee joint angle was assessed using a goniometer placed on the lateral epicondyle of the knee, aligned with the femur, while the anchor arm was aligned with the lateral malleolus. They were instructed to maintain the isometric hold for up to three minutes, or until volitional fatigue was reached.with a 30-second rest period between each squat hold. Immediately post 60 second rest, Determine the participant's maximum angle using the double leg lowering test from supine position let the participant with both legs straightened before lifting the posterior hip, lowering the legs to a specific angle. Turn on the stopwatch. Hold the position near--maximally, try to achieve on (IES=9/10) and hold for the longest duration. They should reach 4 minutes for 3 repetition with 30 seconds rest between repetition

Multiple Isometric wall squat exercise + Double Leg Lower with Isometric Hold

Control quiet seated rest OTHER

The control group served as the control group and did not perform any exercise. Participants were instructed to sit quietly in a standard height stationary clinical room patient chair for the entire eight minutes.

Control quiet seated rest

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• participants aged ≥18 years or older
• participant diagnosed with non-specific chronic lower back pain (\> 12 weeks)

You may not qualify if:

• pregnant women 2- lactating women for one or less than one year post-natal. 3- any certain medical conditions that could interfere with physical activity, including:
• uncontrolled diabetes
• cardiovascular problem
• orthopedic impairments
• balance problems. 4-serious spinal pathologies :
• infection
• fractures
• tumors
• inflammatory diseases like ankylosing spondylitis 5- neurological compromise,
• spinal nerve compromise
• cauda equina syndrome

Sponsors & Collaborators

• Taif University: lead

Study Sites (1)

King Abdullah Hospital in bisha

Bisha, 'Asir Region, 67714, Saudi Arabia

RECRUITING

MeSH Terms

Conditions

Low Back Pain

Condition Hierarchy (Ancestors)

Back Pain; Pain; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms

Central Study Contacts

Asma A Alqahtani, B.S.C

CONTACT

966504435372; Alqahtaniasma61@gmail.com

Hosam A Alzahrani, PHD

CONTACT

966550668282; halzahrani@tu.edu.sa

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: DOUBLE
• Who Masked: INVESTIGATOR, OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate professor

Study Record Dates

• First Submitted: March 13, 2025
• First Posted: May 9, 2025
• Study Start: August 1, 2025
• Primary Completion: October 1, 2025
• Study Completion: January 1, 2026
• Last Updated: September 4, 2025

Record last verified: 2025-08

Data Sharing

• IPD Sharing: Will not share

Locations

SA (1)