Perioperative Homocysteine and Postoperative Complications/All-Cause Mortality in Elderly Non-Cardiac Surgery Patients

NCT06959446 | Completed

• 1 other identifier: PLAGH-AOC-L07
• Study Type: observational
• Target: 12,955
• Locations: 0 countries
• Sites: N/A

Brief Summary

This study aims to explore the association between perioperative homocysteine (Hcy) levels and their pre-to-postoperative changes with postoperative complications and all-cause mortality in elderly patients undergoing non-cardiac surgery. Besides, the dynamic changes in Hcy levels may reflect metabolic shifts, highlighting their potential value in predicting adverse postoperative outcomes. These findings suggest that monitoring perioperative Hcy levels and their changes could help identify high-risk patients and inform postoperative management strategies.

Conditions

Elderly; Homocysteinemia; AKI - Acute Kidney Injury; Mortality; Postoperative

Outcome Measures

Primary Outcomes (1)

• Acute kidney injury (AKI)

  January 2014 - August 2019

Secondary Outcomes (1)

• mortality

  January 2014 - August 2020

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

An observational study using data from the First Medical Center of Chinese PLA General Hospital, an electronic medical record-based data set of 12,955 older patients (≥ 65 years) who had surgery between January 2014 to August 2019

You may qualify if:

• Hospitalized older (≥ 65 years) patients underwent non-cardiac surgery

You may not qualify if:

• patients without preoperative Hcy data
• patients undergoing neurosurgery
• patients call off the surgery for reasons
• patients with chronic kidney disease

Sponsors & Collaborators

• Chinese PLA General Hospital: lead

MeSH Terms

Conditions

Homocysteinemia; Acute Kidney Injury

Condition Hierarchy (Ancestors)

Renal Insufficiency; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: April 28, 2025
• First Posted: May 6, 2025
• Study Start: January 1, 2014
• Primary Completion: August 30, 2019
• Study Completion: August 30, 2020
• Last Updated: May 20, 2025

Record last verified: 2025-05