NCT06958523

Brief Summary

The Apple Health Study aims to build a diverse and inclusive group of participants to help researchers advance our understanding of how signals and information collected from apps and devices relate to health and may be used to predict, detect, monitor, and manage changes in health. To enroll, US residents who have an iPhone can download the Apple Research app from the App Store and go through the introduction and informed consent for the Apple Health Study. This study is fully remote, and all are invited to enroll if the eligibility criteria are met. Participants will be asked to complete tasks and surveys, using their iPhone and Apple Research app which include:

  • Selecting the types of data they would like to share with the study such as health and sensor data
  • Completing tasks and surveys including areas such as personal demographic information, personal medical history, family history, and social determinants of health

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
500,000

participants targeted

Target at P75+ for all trials

Timeline
45mo left

Started Feb 2025

Longer than P75 for all trials

Geographic Reach
1 country

2 active sites

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress27%
Feb 2025Feb 2030

Study Start

First participant enrolled

February 12, 2025

Completed
21 days until next milestone

First Submitted

Initial submission to the registry

March 5, 2025

Completed
2 months until next milestone

First Posted

Study publicly available on registry

May 6, 2025

Completed
4.7 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

February 1, 2030

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

February 1, 2030

Last Updated

July 29, 2025

Status Verified

July 1, 2025

Enrollment Period

5 years

First QC Date

March 5, 2025

Last Update Submit

July 24, 2025

Conditions

Mental HealthSleepExerciseHormonesMetabolic HealthHearingAgingLifestyle FactorsFunctional CapacityNeurological ConditionsGeneral HealthWellbeingWomen's Health

Keywords

Apple Health StudyLarge Scale Digital StudyDigital BiomarkersResearch AppApple Research AppiPhone

Outcome Measures

Primary Outcomes (1)

  • Health Status

    Assessed by participant self-report as well as clinical health records and claims data. The initial count and change over time in the number and type of health conditions such as cardiovascular, circulatory, cognition, hearing, mental health, metabolic, mobility, neurologic, respiratory, sex and gender, reproduction, hormones, sleep, and health events such as hospitalizations, procedures or falls.

    Baseline and every 6 months until study end (up to 5 years)

Secondary Outcomes (3)

  • Participant Population: Demographic Characteristics of Study Participants

    Baseline and annually until study end (up to 5 years)

  • Social Determinants of Health: Lifestyle & Environment Survey

    Baseline and every 6 months until study end (up to 5 years)

  • Family Health History in Health Conditions and Health Events

    Baseline and have option to update if needed (up to 5 years)

Eligibility Criteria

Age18 Years+
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64), Older Adult (65+)
Sampling MethodNon-Probability Sample
Study Population

The Study aims to enroll a large and representative group of at least 500,000 participants across the United States of America willing to contribute information about health and wellness over time.

You may qualify if:

  • Be at least 18 years old (at least 19 years old in Alabama and Nebraska, at least 21 years old in Puerto Rico);
  • Live in the United States of America;
  • Have an iPhone;
  • Have installed Apple Research app on your iPhone;
  • Be comfortable communicating in written and spoken English;
  • Be willing and able to provide informed consent to participate in the Study.

You may not qualify if:

  • Share your iCloud account, iPhone, or devices that collect health data such as Apple Watch with anyone else, because it could result in sharing another person's health information with the Study, making it challenging for researchers to use your information.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (2)

MCRA

Washington D.C., District of Columbia, 20001, United States

RECRUITING

Brigham and Women's Hospital

Boston, Massachusetts, 02115, United States

RECRUITING

Related Links

MeSH Terms

Conditions

Psychological Well-BeingMotor Activity

Condition Hierarchy (Ancestors)

Personal SatisfactionBehavior

Study Officials

  • Calum MacRae, MD, PhD

    Brigham and Women's Hospital

    PRINCIPAL INVESTIGATOR

  • Tiffany Avery, MD

    MCRA

    PRINCIPAL INVESTIGATOR

Central Study Contacts

MCRA Study Call Center

CONTACT

833-600-6993applehealthstudy@bwh.harvard.edu

Study Design

Study Type
observational
Observational Model
COHORT
Time Perspective
CROSS SECTIONAL
Target Duration
5 Years
Sponsor Type
INDUSTRY
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Vice Chair for Scientific Innovation, Department of Medicine

Study Record Dates

First Submitted

March 5, 2025

First Posted

May 6, 2025

Study Start

February 12, 2025

Primary Completion (Estimated)

February 1, 2030

Study Completion (Estimated)

February 1, 2030

Last Updated

July 29, 2025

Record last verified: 2025-07

Locations

US(2)