Myocardial Injury Noncardiac Surgery in Geriatric Patients

NCT06957106 | Completed

• 1 other identifier: FSMTRH-MBN-02
• Study Type: observational
• Target: 117
• Locations: 1 country
• Sites: 1

Brief Summary

In inpatients aged 45 years and older, the approximate peri-operative mortality rate after non-cardiac surgery is around 1% to 2%. Half of these deaths are attributed to cardiovascular complications of surgery. Postoperative cardiac troponin elevation with ≥1 measurement of cardiac troponin ≥99% percentile above the upper limit of the reference value, which is an indicator of acute myocardial injury, is seen in the first 30 days after surgery and usually occurs within 72 hours. Myocardial damage is thought to result from an ischemic mechanism. Clinical symptoms may be masked by sedation or analgesia in the perioperative period, so evidence of an ischemic feature (e.g. ischemic symptoms, electrocardiographic changes) is not required. These criteria are defined as MINS (Myocardial Injury Non Cardiac Surgery) criteria. In this study, the investigators aimed to investigate the intensive care follow-up processes and outcomes of geriatric patients over 65 years of age in whom MINS was detected during postoperative intensive care monitoring.

Conditions

Myocardial Injury After Noncardiac Surgery (MINS)

Keywords

myocardial injury; intensive care unit; geriatric patients; troponin elevation; ICU outcomes; Anesthesia

Outcome Measures

Primary Outcomes (1)

• 30-day postoperative mortality

  Association between postoperative troponin elevation and ICU mortality in geriatric patients. Mortality status recorded in hospital database

  30 days

Secondary Outcomes (1)

• mechanical ventilation

  30 days

Study Arms (1)

Geriatric ICU Patients

Geriatric patients (aged ≥65 years) who underwent surgery under general or regional anesthesia and were admitted to the intensive care unit in the postoperative period between January 2018 and August 2023.

Eligibility Criteria

• Age: 65 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study includes geriatric patients aged 65 years and older who underwent major, moderate, or minor surgery under general and/or regional anesthesia and were followed postoperatively in the intensive care unit between January 2018 and August 2023 at Fatih Sultan Mehmet Training and Research Hospital. The study population consists of patients whose medical records were retrospectively reviewed.

You may qualify if:

• Patients aged 65 years or older
• Patients who underwent major, moderate, or minor surgery under general and/or regional anesthesia
• Patients who were followed and treated in the postoperative intensive care unit

You may not qualify if:

• Patients younger than 65 years of age
• Patients with preoperative troponin levels above the normal reference range
• Patients with active myocardial ischemia symptoms (e.g., chest pain, pain radiating to the neck, jaw, shoulder, or arm)
• Patients with known pre-existing cardiac disease

Sponsors & Collaborators

• Fatih Sultan Mehmet Training and Research Hospital: lead

Study Sites (1)

Fatih Sultan Mehmet Training and Research Hospital,

Istanbul, Atasehir, 34752, Turkey (Türkiye)

Location

Related Publications (3)

• Gao L, Chen L, He J, Wang B, Liu C, Wang R, Fan L, Cheng R. Perioperative Myocardial Injury/Infarction After Non-cardiac Surgery in Elderly Patients. Front Cardiovasc Med. 2022 May 19;9:910879. doi: 10.3389/fcvm.2022.910879. eCollection 2022.

  PMID: 35665266 BACKGROUND

• Park J, Lee JH. Myocardial injury in noncardiac surgery. Korean J Anesthesiol. 2022 Feb;75(1):4-11. doi: 10.4097/kja.21372. Epub 2021 Oct 18.

  PMID: 34657407 BACKGROUND

• Ruetzler K, Smilowitz NR, Berger JS, Devereaux PJ, Maron BA, Newby LK, de Jesus Perez V, Sessler DI, Wijeysundera DN. Diagnosis and Management of Patients With Myocardial Injury After Noncardiac Surgery: A Scientific Statement From the American Heart Association. Circulation. 2021 Nov 9;144(19):e287-e305. doi: 10.1161/CIR.0000000000001024. Epub 2021 Oct 4.

  PMID: 34601955 BACKGROUND

Study Officials

• Arzu Yildirim Ar, As Prof

  Fatih Sultan Mehmet Training and Research Hospital

  STUDY DIRECTOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: resident doctor

Study Record Dates

• First Submitted: April 21, 2025
• First Posted: May 4, 2025
• Study Start: January 1, 2018
• Primary Completion: August 1, 2023
• Study Completion: August 1, 2023
• Last Updated: May 4, 2025

Record last verified: 2025-01

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)