Bilirubin Levels to Diagnose Appendicitis and Predict Appendiceal Perforation

NCT06956638 | Completed DMC

• 1 other identifier: IRB604
• Study Type: observational
• Target: 98
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this study is to learn if serum bilirubin levels can aid in the diagnosis of acute appendicitis and predict appendiceal perforation

Conditions

Acute Appendicitis; Appendicitis Perforated

Keywords

Single-center; prospective; cross-sectional

Outcome Measures

Primary Outcomes (1)

• Perforated appendix

  Perforated appendicitis was confirmed intraoperatively by the surgeon and at histological analysis of the specimen by the rupture of appendiceal wall to the serosa. Those with gangrenous walls were also taken as perforated.

  Presentation to hospital till perioperative period

Study Arms (1)

Patients of age group above 5 years with acute appendicitis undergoing appendectomy

Patients of age group above 5 years with acute appendicitis undergoing appendectomy, without acute or chronic liver diseases, acquired or congenital bilirary diseases, history of use of hepatotoxic drugs or diagnosis of appendicular lump

Other: Non-interventional

Interventions

Non-interventional OTHER

Non-interventional study

Patients of age group above 5 years with acute appendicitis undergoing appendectomy

Eligibility Criteria

• Age: 5 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting with acute appendicitis at Shree Birendra Hospital, Chhauni, Kathmandu

You may qualify if:

• Patients of age group above 5 years with acute appendicitis undergoing appendectomy with written informed consent.

You may not qualify if:

• Patients with appendicular lump.
• Patients with acute and chronic liver diseases like acute hepatitis, hemolytic disease, Gilbert's syndrome, Dubin-Johnson syndrome, alcoholic liver disease.
• Acquired or Congenital Biliary Disease.
• History of Hepatotoxic drugs.

Sponsors & Collaborators

• Nepalese Army Institute of Health Sciences: lead

Study Sites (1)

Shree Birendra Hospital

Kathmandu, Bagmati, 44620, Nepal

Location

Related Publications (4)

• Sirikurnpiboon S, Amornpornchareon S. Factors Associated with Perforated Appendicitis in Elderly Patients in a Tertiary Care Hospital. Surg Res Pract. 2015;2015:847681. doi: 10.1155/2015/847681. Epub 2015 Aug 24.

  PMID: 26380377 RESULT

• Potey K, Kandi A, Jadhav S, Gowda V. Study of outcomes of perforated appendicitis in adults: a prospective cohort study. Ann Med Surg (Lond). 2023 Mar 16;85(4):694-700. doi: 10.1097/MS9.0000000000000277. eCollection 2023 Apr.

  PMID: 37113955 RESULT

• Chaudhary P, Kumar A, Saxena N, Biswal UC. Hyperbilirubinemia as a predictor of gangrenous/perforated appendicitis: a prospective study. Ann Gastroenterol. 2013;26(4):325-331.

  PMID: 24714371 RESULT

• Sand M, Bechara FG, Holland-Letz T, Sand D, Mehnert G, Mann B. Diagnostic value of hyperbilirubinemia as a predictive factor for appendiceal perforation in acute appendicitis. Am J Surg. 2009 Aug;198(2):193-8. doi: 10.1016/j.amjsurg.2008.08.026. Epub 2009 Mar 23.

  PMID: 19306980 RESULT

Related Links

• Related Info

MeSH Terms

Conditions

Appendicitis

Condition Hierarchy (Ancestors)

Intraabdominal Infections; Infections; Gastroenteritis; Gastrointestinal Diseases; Digestive System Diseases; Cecal Diseases; Intestinal Diseases

Study Officials

• Bhairav Kumar Hamal, MS, Fellow - Urosurgery

  Nepalese Army Institute of Health Sciences

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 24, 2025
• First Posted: May 4, 2025
• Study Start: July 16, 2022
• Primary Completion: June 15, 2023
• Study Completion: March 12, 2025
• Last Updated: May 7, 2025

Record last verified: 2025-05

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR

Locations

NE (1)