Chest Physical Therapy on Arterial Blood Gases for Neonates Post Hypoxic Ischemic Encephalopathy

NCT06950723 | Not Yet Recruiting DMC

• 1 other identifier: Sayed75
• Study Type: interventional
• Target: 50
• Locations: 0 countries
• Sites: N/A

Brief Summary

Hypoxic-ischemic encephalopathy (HIE) is a dangerous illness that happens when a newborn's brain does not receive adequate oxygen and blood flow, which can result in serious effects such as cerebral palsy and epilepsy. Infant diagnosed with HIE required ventilator support and subsequently developed pneumonia. They experienced respiratory problems and feeding challenges. Chest Physical Therapy is the best modalities to clear chest and improve ventilation.

Conditions

Hypoxic Ischemic Encephalopathy of Newborn

Outcome Measures

Primary Outcomes (4)

• Timing of Arterial blood gases improvement

  Time needed to improve Arterial blood gases due to CPT

  3-14 days

• Timing required for clinical improvement

  Time needed to improve clinical signs due to CPT

  3-14 days

• Timing needed for Mechanical Ventilation

  Time needed to Mechanical Ventilation support.

  3-7 days

• Hospitalization time

  All staying duration need for the neonates from admission till discharge from the hospital.

  5-21 days

Study Arms (2)

Chest physical Therapy group

EXPERIMENTAL

Study group

Other: Chest Physical Therapy (CPT) modalities , Medical Treatment

Medical treatment group

EXPERIMENTAL

Control group

Other: Chest Physical Therapy (CPT) modalities , Medical Treatment

Interventions

Chest Physical Therapy (CPT) modalities , Medical Treatment OTHER

Chest Physical Therapy (CPT) modalities in the form of postural drainage, percussion and vibration.

Chest physical Therapy group; Medical treatment group

Eligibility Criteria

• Age: 1 Day - 10 Days
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17)

You may qualify if:

• Neonates with chest problems post Hypoxic-ischemic encephalopathy

You may not qualify if:

• Neonates with chest problems due to other Causes except post Hypoxic-ischemic encephalopathy.
• unstable medical status
• Neonates with Post-operative s' respiratory problems due to any reasons.

Sponsors & Collaborators

• Cairo University: lead

MeSH Terms

Interventions

2-cyclohexylidenhydrazo-4-phenyl-thiazole

Central Study Contacts

Elsayed Mehrem, Associate Professor

CONTACT

+201006973334; sayed7555@yahoo.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: PARTICIPANT
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: April 9, 2025
• First Posted: April 30, 2025
• Study Start: May 10, 2025
• Primary Completion: June 10, 2025
• Study Completion: July 15, 2025
• Last Updated: April 30, 2025

Record last verified: 2025-04