Hemogram Parameter Changes With Sepsis Filter

NCT06948630 | Completed

• 1 other identifier: Istinye University
• Study Type: observational
• Target: 92
• Locations: 1 country
• Sites: 1

Brief Summary

Hemodiafiltration is initiated in hemodynamically unstable patients in intensive care units. In some patients, additional devices called cytokine filters or sepsis filters are added to remove inflammatory cytokines. Data obtained from hemograms, such as platelet lymphocytosis ratio, are used in the diagnosis or prognosis of many diseases. This study focuses on the change in hemogram rates in patients who received hemofiltration and sepsis filters.

Conditions

Platelet Abnormality; Renal Failure; Immune System Disorder

Outcome Measures

Primary Outcomes (1)

• Platelet lymphocyte ratio change

  Change in platelet lymphocyte ratio measured from hemogram at the beginning (day 0) and the ratio calculated from the sample taken on day 3 in patients undergoing hemodiafiltration with sepsis filter

  up to 72 hours

Secondary Outcomes (1)

• change in the other ratios derived from complete blood cell count

  up to 72 hours

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Hemodiafiltration is started on patients in intensive care units. This study focuses on the change in hemogram rates in patients who underwent hemofiltration and had sepsis filters placed.

You may qualify if:

• Data of patients who were monitored in the Intensive Care between January 2020 and December 2022 and who were applied sepsis filters

You may not qualify if:

• Patients who underwent hemodiafiltration with sepsis filter but could not be followed for 72 hours (death, etc.)

Sponsors & Collaborators

• Samsun University: lead

Study Sites (1)

Istinye University

Istanbul, Turkey (Türkiye)

Location

Related Publications (2)

• Nassiri AA, Schneider A, Hakemi MS, Sabaghian T, Ahmadi Koomleh A, Miri MM, Entezarmahdi K, Yousefzad T, Kashani K. Scientia et Cura: Illuminating the Dark Side of CRRT for Optimal Patient Benefits. Iran J Kidney Dis. 2025 Feb 25;19(1):50-58.

  PMID: 40056440 BACKGROUND

• Wu D, Qin H. Diagnostic and prognostic values of immunocyte ratios in patients with sepsis in the intensive care unit. J Infect Dev Ctries. 2023 Oct 31;17(10):1362-1372. doi: 10.3855/jidc.17907.

  PMID: 37956370 RESULT

MeSH Terms

Conditions

Blood Platelet Disorders; Renal Insufficiency; Immune System Diseases

Condition Hierarchy (Ancestors)

Hematologic Diseases; Hemic and Lymphatic Diseases; Kidney Diseases; Urologic Diseases; Female Urogenital Diseases; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Male Urogenital Diseases

Study Officials

• Erkan Bayram

  Istınye university faculity of Medicine

  STUDY CHAIR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 21, 2025
• First Posted: April 29, 2025
• Study Start: January 1, 2024
• Primary Completion: February 1, 2024
• Study Completion: February 1, 2024
• Last Updated: April 29, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)