Preoperative Study of the Correlation Between BDNF-TrkB Signaling Pathway Expression Levels in Cerebrospinal Fluid and Blood and Postpartum Depression

NCT06947278 | Completed DMC

• 1 other identifier: KY-20240701001-02
• Study Type: observational
• Target: 200
• Locations: 1 country
• Sites: 1

Brief Summary

This single-center prospective observational study will screen 200 parturients with combined lumbo-epidural anesthesia in the First People's Hospital of Lianyungang City, collect the basic information of the patients, as well as the scores of PSQI, STAI, NRS, SSRS and other scales one day before surgery, and analyze their effects on the expression level of BDNF. On the day of surgery, 10mL of peripheral arterial blood and 3 mL of cerebrospinal fluid were collected, and the expression levels of BDNF-TrkB signaling pathway (ProBDNF, mBDNF, TrkB, P-CREB and ALB) were measured, respectively. The patient's EPDS and HAMD-21 scores were evaluated and collected by a professional psychologist at 1 day before surgery, 7 days after surgery, and 42 days after surgery, and the correlation between BDNF expression level and the occurrence of postpartum depression was statistically analyzed, as well as which in cerebrospinal fluid and blood was more sensitive for predicting postpartum depression.

Conditions

Postpartum Depression (PPD)

Keywords

prospective observational studies;; Postpartum Depression(PPD); brain-derived neurotrophic factor (BDNF); Edinburgh postnatal depression scale (EPDS); Hamilton depression scale (HAMD-21)

Outcome Measures

Primary Outcomes (1)

• Correlation between the expression level of BDNF-TrkB signaling pathway (mBDNF, proBDNF) in cerebrospinal fluid and blood and postpartum depression;

  Blood and cerebrospinal fluid samples were collected before anesthesia administration on the day of surgery, placed in a -80 degree Celsius freezer, and mBDNF and proBDNF concentrations were measured within 3 months after sample collection.

Secondary Outcomes (2)

• Comparison of the sensitivity of cerebrospinal fluid and blood levels of BDNF in predicting postpartum depression;

  Blood and cerebrospinal fluid samples were collected before anesthesia administration on the day of surgery, placed in a -80 degree Celsius freezer, and BDNF concentrations were measured within 3 months after sample collection.

• The correlation between BDNF (mBDNF, proBDNF) concentrations in cerebrospinal fluid and blood.

  Blood and cerebrospinal fluid samples were collected before anesthesia administration on the day of surgery, placed in a -80 degree Celsius freezer, and albumin concentrations were measured within 3 months after sample collection.

Eligibility Criteria

• Age: 20 Years - 35 Years
• Sex: female
• Healthy Volunteers: No
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

Patients undergoing elective cesarean section under combined lumbar-rigid anesthesia in the First People's Hospital of Lianyungang City

You may qualify if:

• Meet the indications for cesarean section and have no contraindications to neuraxial anesthesia;
• years old≤ age ≤ 35 years old;
• ≤ gestational age\< 42;
• American Society of Anesthesiologists (ASA) grade II\~III;
• singleton pregnancy;
• Voluntarily participate in this study and sign the informed consent form.

You may not qualify if:

• Unable to understand the content of the questionnaire correctly;
• a clear history of mental illness, depression, cognitive impairment and other diseases;
• Patients who have been taking sedative, analgesic and psychotropic drugs for a long time;
• Those who have recently used glucocorticoids or immunosuppressants;
• Those who are allergic to or have contraindications to any of the drugs used in this study;
• Serious pregnancy complications, such as preeclampsia, placental hyperplasia, etc.;
• Participated in other clinical studies within the last 3 months.

Sponsors & Collaborators

• The First People's Hospital of Lianyungang: lead

Study Sites (1)

The Affiliated Lianyungang Hospital of Xuzhou Medical University

Lianyungang, Jiangsu, 222000, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

cerebrospinal fluid and blood

MeSH Terms

Conditions

Depression, Postpartum

Condition Hierarchy (Ancestors)

Puerperal Disorders; Pregnancy Complications; Female Urogenital Diseases and Pregnancy Complications; Urogenital Diseases; Depressive Disorder; Mood Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 12, 2025
• First Posted: April 27, 2025
• Study Start: May 1, 2025
• Primary Completion: November 16, 2025
• Study Completion: November 16, 2025
• Last Updated: December 2, 2025

Record last verified: 2025-11

Data Sharing

• IPD Sharing: Will not share

Locations

CN (1)