LIFE-TB ; Long-Term Impacts on Lung Health and Life After Tuberculosis in Korea
1 other identifier
observational
360
1 country
1
Brief Summary
This is a prospective, multicenter observational cohort study aimed at establishing a nationwide post-TB lung disease registry in Korea. The study will enroll adult participants either undergoing treatment for pulmonary tuberculosis or with a history of treated TB. Over a five-year follow-up period, the study will assess the long-term health consequences of TB, focusing on respiratory symptoms, radiological changes, pulmonary function, and quality of life.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at P75+ for all trials
Started Feb 2025
Longer than P75 for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
Click on a node to explore related trials.
Study Timeline
Key milestones and dates
Study Start
First participant enrolled
February 25, 2025
CompletedFirst Submitted
Initial submission to the registry
April 13, 2025
CompletedFirst Posted
Study publicly available on registry
April 27, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
December 31, 2031
ExpectedStudy Completion
Last participant's last visit for all outcomes
December 31, 2031
April 27, 2025
April 1, 2025
6.8 years
April 13, 2025
April 20, 2025
Conditions
Keywords
Outcome Measures
Primary Outcomes (4)
respiratory symptoms
Prevalence and progression of respiratory symptoms (mMRC score, cough, sputum, hemoptysis)
6month , 1year, 2year, 3year, 4year, 5year, 6year
abnormal radiographic findings
abnormal findings of chest X-ray or chest CT
6month , 1year, 2year, 3year, 4year, 5year, 6year
pulmonary function
Pulmonary function measured by spirometry: FEV1, FVC, FEV1/FVC
6month , 1year, 2year, 3year, 4year, 5year, 6year
Quality of life
Quality of life measured by EQ-5D-5L, PROMIS, SGRQ
6month , 1year, 2year, 3year, 4year, 5year, 6year
Secondary Outcomes (1)
poor long-term outcome
6month , 1year, 2year, 3year, 4year, 5year, 6year
Study Arms (1)
Active TB patients initiating or undergoing treatment or Post-treatment TB survivors
Eligibility Criteria
Adult participants either undergoing treatment for pulmonary tuberculosis or with a history of treated TB.
You may qualify if:
- Age ≥19 years
- Diagnosed with pulmonary TB and either initiating or undergoing treatment or history of treated pulmonary TB
You may not qualify if:
- Age \<19 years
- Extrapulmonary TB without lung involvement
- Refusal to provide informed consent
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
Department of Internal Medicine, Yonsei University College of Medicine Division of Pulmonology, Severance Hospital, Yonsei University Health System
Seoul, South Korea
Related Publications (1)
Chung C, Min J, Jeon D, Kwon YS, Mok J, Kim HW, Park Y, Kang YA. Protocol of a Nationwide Observational Cohort Study for Long-Term Impacts on Lung Health and Life after Tuberculosis in Korea (LIFE-TB). Tuberc Respir Dis (Seoul). 2026 Jan;89(1):86-93. doi: 10.4046/trd.2025.0109. Epub 2025 Oct 15.
PMID: 41088970DERIVED
MeSH Terms
Conditions
Condition Hierarchy (Ancestors)
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 13, 2025
First Posted
April 27, 2025
Study Start
February 25, 2025
Primary Completion (Estimated)
December 31, 2031
Study Completion (Estimated)
December 31, 2031
Last Updated
April 27, 2025
Record last verified: 2025-04
Data Sharing
- IPD Sharing
- Will not share