The Effect of Prolonged ischemıa and anesthetıc Agents on Oxidative Stress

NCT06942650 | Completed

• 2 other identifiers: 2019/02Duzce University
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to learn about the relationship between postoperative pain and tourniquet-induced oxidative damage in adults undergoing orthopedic knee arthroscopy surgery.The goal of this observational study is to learn about the relationship between postoperative pain and tourniquet-induced oxidative damage in adults undergoing orthopedic knee arthroscopy surgery. The main question it aims to answer is: Does anesthetic agents used will affect tourniquet-related oxidative stress and postoperative pain ?

Conditions

Tourniquet Pain; Ischemia-reperfusion; Postoperative Pain; Anesthesia; Oxydative Stress

Keywords

Hypoxia-inducible factor alfa; tourniquet pain; anesthesia; ischemia; postoperative pain

Outcome Measures

Primary Outcomes (1)

• To observe the relation between somatic oximeter values and oxidative stress parameters.

  To observe the correlation between INVOS™ 5100C Cerebral/Somatic Oximeter measurements(rSO2) (% value) and oxidative stress parameters \[ Human hypoxia-inducible factor 1α(HIF-1α) ELISA kit (pg/L), Human decay-accelerating factor(DAF/CD55)ELISA (pg/L) \] measurements after tourniquet inflation and before tourniquet deflation.

  1 day

Secondary Outcomes (1)

• The effect of anesthetic agents on oxidative stress parameters.

  1 day

Other Outcomes (1)

• The effect of oxidative stress parameters on 24 hour analgesic needing

  1 day

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Sixty patients aged 18-80, with ASA I-II status, who underwent knee arthroscopy were included in the study. A voluntary consent form was obtained all th e patients.

You may qualify if:

• Patients aged 18-80 years,
• (American society of Anesthesiologist) ASA I-II status,
• undergoing knee arthroscopy.

You may not qualify if:

• Diabetes mellitus,
• advanced chronic obstructive pulmonary disease,
• liver failure,
• renal failure,
• history of previous bypass,
• hemoglobinopathies,
• anemia,
• hypertensive patients,
• neurodegenerative diseases

Sponsors & Collaborators

• Duzce University: lead

Study Sites (1)

İlknur SuidiyeYORULMAZ

Düzce, 81620, Turkey (Türkiye)

Location

MeSH Terms

Conditions

Pain, Postoperative; Ischemia

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms

Study Officials

• İlknur S YORULMAZ, Assoc. Prof.

  Duzce University

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Day
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 18, 2025
• First Posted: April 24, 2025
• Study Start: January 1, 2022
• Primary Completion: January 1, 2024
• Study Completion: August 1, 2024
• Last Updated: April 24, 2025

Record last verified: 2025-04

Locations

TU (1)