Timing for Computed Tomography and Post-Resuscitation Care on Short-Term Outcomes in Out-of-Hospital Cardiac Arrest

NCT06936917 | Not Yet Recruiting

• 1 other identifier: 202409129RINC
• Study Type: observational
• Target: 5,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

This retrospective multicenter study investigates the association between the timing of computed tomography (CT) scans and short-term outcomes in adult non-traumatic out-of-hospital cardiac arrest (OHCA) patients who achieved return of spontaneous circulation (ROSC). The study includes cases from January 1, 2016, to August 31, 2024, across six branches of National Taiwan University Hospital. Data collected include demographics, Utstein variables, emergency department (ED) interventions and their timing. Primary outcomes are survival to admission, and 1-day, 3-day, and 7-day survival. Secondary outcomes focus on the timing and sequence of CT imaging and other interventions in relation to short-term prognosis and ED length of stay. The study aims to explore whether earlier CT utilization can improve outcomes in the post-resuscitation phase of care.

Conditions

Out of Hospital Cardiac Arrest; Computed Tomography

Keywords

Out-of-hospital cardiac arrest; Computed tomography; short-term outcome; resuscitation management; cardiopulmonary resuscitation

Outcome Measures

Primary Outcomes (1)

• Short-term outcomes (1-day, 3-day, and 7-day in-hospital survival)

  Defined as survival at 24, 72, and 168 hours, respectively, following hospital admission.

  24, 72, and 168 hours following hospital admission from ED

Study Arms (1)

OHCA with ROSC and receive CT

Patients who experienced out-of-hospital cardiac arrest, received resuscitative efforts in the emergency department, achieved return of spontaneous circulation (ROSC), and subsequently underwent computed tomography (CT) imaging, regardless of the anatomical region scanned.

Eligibility Criteria

• Age: 20 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with OHCA and ROSC

You may qualify if:

• Adults aged 20 years or older.
• Patients who experienced out-of-hospital cardiac arrest (OHCA), received resuscitative efforts in the emergency department, achieved return of spontaneous circulation (ROSC), and subsequently underwent computed tomography (CT) imaging (regardless of the anatomical region scanned).

You may not qualify if:

• Patients with cardiac arrest due to traumatic causes (traumatic OHCA).
• Patients who were transferred to non-NTUH-affiliated hospitals for post-resuscitation care.
• Patients whose prognosis could not be determined from medical records.
• Patients with incomplete, missing, or otherwise restricted medical records that limited data accessibility or review.

Sponsors & Collaborators

• National Taiwan University Hospital: lead

Related Publications (3)

• Branch KRH, Gatewood MO, Kudenchuk PJ, Maynard C, Sayre MR, Carlbom DJ, Edwards RM, Counts CR, Probstfield JL, Brusen R, Johnson N, Gunn ML. Diagnostic yield, safety, and outcomes of Head-to-pelvis sudden death CT imaging in post arrest care: The CT FIRST cohort study. Resuscitation. 2023 Jul;188:109785. doi: 10.1016/j.resuscitation.2023.109785. Epub 2023 Apr 3.

  PMID: 37019352 BACKGROUND

• Cocchi MN, Lucas JM, Salciccioli J, Carney E, Herman S, Zimetbaum P, Donnino MW. The role of cranial computed tomography in the immediate post-cardiac arrest period. Intern Emerg Med. 2010 Dec;5(6):533-8. doi: 10.1007/s11739-010-0403-8. Epub 2010 May 8.

  PMID: 20454869 BACKGROUND

• Reynolds AS, Matthews E, Magid-Bernstein J, Rodriguez A, Park S, Claassen J, Agarwal S. Use of early head CT following out-of-hospital cardiopulmonary arrest. Resuscitation. 2017 Apr;113:124-127. doi: 10.1016/j.resuscitation.2016.12.018. Epub 2017 Jan 3.

  PMID: 28057527 BACKGROUND

MeSH Terms

Conditions

Out-of-Hospital Cardiac Arrest

Condition Hierarchy (Ancestors)

Heart Arrest; Heart Diseases; Cardiovascular Diseases

Central Study Contacts

Chien-Tai Huang, M.D.

CONTACT

+886-3-5326151; b9920802727@gmail.com

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 13, 2025
• First Posted: April 20, 2025
• Study Start (Estimated): December 31, 2027
• Primary Completion (Estimated): December 31, 2027
• Study Completion (Estimated): December 31, 2027
• Last Updated: November 19, 2025

Record last verified: 2024-12

Data Sharing

• IPD Sharing: Will not share