Cortical Effects of Peripheral Proprioceptive Stimulation on the Motor Evoked Potentials of the Limbs

NCT06936579 | Not Yet Recruiting

• 1 other identifier: 2025-04-07
• Study Type: interventional
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

Through motor muscle potentials, we will observe how a peripheral somatosensory mechanical stimulus on key limb musculature communicates signals via afferent sensory fibers that encode proprioceptive signals from muscle spindles (particularly type Ia fibers) to the somatosensory cortex at rest, confirming the integrative hypothesis of movement. These results would support interventions aimed at addressing sensory deafferentation present in multiple health conditions related to movement disorders, where disuse or immobilization lead to changes in movement patterns and a decrease in neuronal activation in somatosensory cortex areas involved in constructing voluntary movement.

Conditions

Healthy Subjects

Outcome Measures

Primary Outcomes (1)

• Motor evoked potentials (MEPs)

  transcranial magnetic stimulation (TMS)

  45 minuts

Study Arms (3)

Condition without proprioceptive stimulation:

NO INTERVENTION

Participants will not receive the stimulus, and MEP activity will be recorded under the same motor cortex stimulation conditions.

Condition with proprioceptive stimulation 1

EXPERIMENTAL

Participants will receive proprioceptive stimulation through the output plunger, applied continuously for 15 seconds, with 20-second rest intervals, over a total duration of 5 minutes. MEP activity will then be recorded via motor cortex stimulation.

Device: proprioceptive stimulation

Condition with proprioceptive stimulation 2

ACTIVE COMPARATOR

Participants will receive proprioceptive stimulation continuously during the application of TMS pulses while MEP activity is recorded.

Device: proprioceptive stimulation

Interventions

proprioceptive stimulation DEVICE

Condition without proprioceptive stimulation: Participants will not receive the stimulus, and MEP activity will be recorded under the same motor cortex stimulation conditions. Condition with proprioceptive stimulation 1: Participants will receive proprioceptive stimulation through the output plunger, applied continuously for 15 seconds, with 20-second rest intervals, over a total duration of 5 minutes. MEP activity will then be recorded via motor cortex stimulation. Condition with proprioceptive stimulation 2: Participants will receive proprioceptive stimulation continuously during the application of TMS pulses while MEP activity is recorded.

Condition with proprioceptive stimulation 1; Condition with proprioceptive stimulation 2

Eligibility Criteria

• Age: 18 Years - 80 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Good health status with no history of neuromuscular injuries, surgical interventions, or trauma affecting the central or peripheral nervous system.
• Not currently taking drugs or medications known to affect the central nervous system, and not pregnant at the time of testing.
• No metallic or electronic implants and no history of epilepsy.
• (Safety, ethical considerations, and application guidelines for the use of transcranial magnetic stimulation in clinical practice and research)

Sponsors & Collaborators

• Facultat de ciencies de la Salut Universitat Ramon Llull: lead

Study Sites (1)

Pedro Victor López Plaza

Barcelona, Spain

Location

Central Study Contacts

Pedro V López Plaza

CONTACT

932 53 32 56; pedrovictorlp@gmail.com

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: RANDOMIZED
• Masking: SINGLE
• Who Masked: OUTCOMES ASSESSOR
• Purpose: TREATMENT
• Intervention Model: CROSSOVER
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator,

Model Details: Each participant will serve as their own control and will be assessed under both stimulation (experimental) and no-stimulation (control) conditions

Study Record Dates

• First Submitted: April 12, 2025
• First Posted: April 20, 2025
• Study Start: May 20, 2025
• Primary Completion: July 15, 2025
• Study Completion: July 30, 2025
• Last Updated: April 24, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

ES (1)