Tissue Expression of Krüppel-Like Factors 4 and 7 in Bone Tumors

NCT06935864 | Recruiting DMC

• 1 other identifier: FMASU MD173/2024
• Study Type: observational
• Target: 30
• Locations: 1 country
• Sites: 2

Brief Summary

The current study is to assess the prognostic value of Krüppel-like factors 4 and 7 in bone tumors, and its role in the disease progression.

Conditions

Osteosarcoma in Children; Ewing Sarcoma of Bone or Soft Tissue

Keywords

Bone Tumor; Osteosarcoma; Ewing sarcoma

Outcome Measures

Primary Outcomes (1)

• The prognostic value

  Assess the prognostic value of Krüppel-like factors 4 and 7 in bone tumors,

  1 year

Study Arms (1)

Prospective Arm

Children, young adolescents younger than 15 years, and young adults (15 to 39 years) with histologically confirmed patients with skeletal or extra-skeletal OS or ES with localized or metastatic disease stages.

Diagnostic Test: KLF factor (4 and 7)

Interventions

KLF factor (4 and 7) DIAGNOSTIC_TEST

Immunohistochemical staining of 4 um sections prepared from paraffin blocks using KLF factor (4 and 7) by automated immunostaining using the streptavidin-biotin technique.

Prospective Arm

Eligibility Criteria

• Age: 1 Month - 39 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Children, adolescents, and young adults diagnosed with localized and metastatic both skeletal and extra-skeletal osteosarcoma and Ewing's sarcoma

You may qualify if:

• Age: children, young adolescents younger than 15 years, and young adults (15 to 39 years) Gender: Males and female. Histologically confirmed patients with skeletal or extra-skeletal OS or ES. Both localized and metastatic disease stages.

You may not qualify if:

• Patients with second malignant bone sarcoma. Patients with benign bone tumors.

Sponsors & Collaborators

• Ain Shams University: lead

Study Sites (2)

Ain Shams University

Cairo, 11566, Egypt

RECRUITING

Faculty of Medicine Ain Shams Research Institute- Clinical Research Center (MASRI-CRC)

Cairo, 11566, Egypt

RECRUITING

Related Links

• Related Info

MeSH Terms

Conditions

Bone Neoplasms; Osteosarcoma; Sarcoma, Ewing

Condition Hierarchy (Ancestors)

Neoplasms by Site; Neoplasms; Bone Diseases; Musculoskeletal Diseases; Neoplasms, Bone Tissue; Neoplasms, Connective Tissue; Neoplasms, Connective and Soft Tissue; Neoplasms by Histologic Type; Sarcoma

Study Officials

• Fatma S E Ebeid

  Faculty of Medicine Ain Shams University

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Fatma S E Ebeid, MD

CONTACT

01095569596; fatmaebeid@med.asu.edu.eg

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: January 5, 2025
• First Posted: April 20, 2025
• Study Start: August 16, 2024
• Primary Completion: December 1, 2025
• Study Completion: February 1, 2026
• Last Updated: April 20, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will not share

Locations

EG (2)