Endoprosthetic Replacement for Pathological Fractures of the Hip: A 35-year Update

NCT06935071 | Active Not Recruiting

• 1 other identifier: 16-1122
• Study Type: observational
• Target: 300
• Locations: 1 country
• Sites: 1

Brief Summary

This study will be based on a retrospective review of patients who received endoprosthetic reconstruction for pathologic fracture of the proximal femur. The objectives would be two-fold: (1) to compare rates ofambulation, pain, and survival to the historic cohort and (2) to identify predictors of ambulation in the current population.

Conditions

Hip Fractures; Hip Fracture Pathologic; Pathological Fracture; Pathological Fracture of Hip

Keywords

hip fractures; pathological hip fractures; hip fracture parthologic; pathological fracture of hip; 16-1122; Memorial Sloan Kettering Cancer Center

Outcome Measures

Primary Outcomes (1)

• Comparison of rates of ambulation, pain, and survival to the historic cohort

  This study will be based on a retrospective review of patients who received endoprosthetic reconstruction for pathologic fracture of the proximal femur.

  up to 10 years

Study Arms (1)

Participants who received endoprosthetic reconstruction

Participants have received endoprosthetic reconstruction for pathologic fracture of the proximal femur.

Other: Data Collection and Analysis

Interventions

Data Collection and Analysis OTHER

Patient data will be analyzed to ensure that all data fields are available and that suitable sample size is available to answer the research objectives. The rate of ambulation at discharge, ambulation at 3 month follow up (if available), time to death, and pain score between the historic cohort with a current cohort of patients will be compared.

Participants who received endoprosthetic reconstruction

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

For this retrospective data review, the study team will query the orthopaedic caisis database and IDB to obtain a list of all participants who have received endoprosthetic reconstruction for pathologic fracture of the proximal femur.

You may qualify if:

• Participants have received endoprosthetic reconstruction for pathologic fracture of the proximal femur

You may not qualify if:

• Participants with fractures greater than 3mm from the lesser trochanter
• Participants without histopathologic confirmation of tumor

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center: lead

Study Sites (1)

Memorial Sloan Kettering Cancer Center

New York, New York, 10065, United States

Location

Related Links

• Memorial Sloan Kettering Cancer Center

MeSH Terms

Conditions

Hip Fractures; Fractures, Spontaneous

Interventions

Data Collection

Condition Hierarchy (Ancestors)

Femoral Fractures; Fractures, Bone; Wounds and Injuries; Hip Injuries; Leg Injuries

Intervention Hierarchy (Ancestors)

Epidemiologic Methods; Investigative Techniques; Health Care Evaluation Mechanisms; Quality of Health Care; Health Care Quality, Access, and Evaluation; Public Health; Environment and Public Health

Study Officials

• John Healey, MD

  Memorial Sloan Kettering Cancer Center

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 11, 2025
• First Posted: April 18, 2025
• Study Start: August 4, 2016
• Primary Completion (Estimated): August 4, 2026
• Study Completion (Estimated): August 4, 2026
• Last Updated: April 16, 2026

Record last verified: 2026-04

Data Sharing

• IPD Sharing: Will share

Locations

US (1)