Prevalence of Types and Patterns of Gastrointestinal Polyps in Assiut University Hospitals ( Cross Sectional Study

NCT06929117 | Not Yet Recruiting

• 1 other identifier: Prevalence of GIT POlyps
• Study Type: observational
• Target: 130
• Locations: 0 countries
• Sites: N/A

Brief Summary

Gastrointestinal polyps (GIPs) are unusual growths of epithelial tissue projecting from the mucosa of gastrointestinal tract (GIT) and one of the most common pathologies affecting GIT . They are either proliferative or neoplastic mucosal lesions that are commonly seen in the colon and less commonly occur in the esophagus, stomach and small intestine. They may remain asymptomatic or present as bleeding, pain and obstruction due to mass effect. However, the most important risk with the gastrointestinal polyps is the development of malignancy in some of these polyps . Gastric polyps include hyperplastic, fundic gland polyps, inflammatory fibroid polyp, adenomas like pyloric gland adenoma, and oxyntic gland adenoma. Hyperplastic gastric polyps rarely undergo neoplastic progression (1.5-2.1%) but are associated with an increased risk of synchronous cancer occurring elsewhere in the gastric mucosa . Gastric adenomas are true neoplasms and precursors of gastric cancer. Adenomas larger than 20 mm in width and villous histology have a higher risk of neoplastic progression . The presence of gastric adenomas is strongly associated with synchronous or metachronous gastric adenocarcinoma . Polyps of the small bowel are rare compared to those of the colo-rectum, with adenomas being most common and having more preference for the distal duodenum, ampullary, and periampullary region Colonic Polyps may be classified according to their gross appearance (sessile or pedunculated), histopathological features (hyperplastic, adenoma, etc.), and behavior (benign or malignant). The biggest concern is their ability to progress into adenocarcinoma, through the adenoma to carcinoma sequence due to genetic mutation .

Conditions

GI Cancer

Outcome Measures

Primary Outcomes (1)

• To assess the presence and grade of dysplasia either low grade or high grade dysplasia in all examined polyps.

  To assess the presence and grade of dysplasia either low grade or high grade dysplasia in all examined polyps.

  during the period from January 2022 to December 2024

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This cross-sectional study will be conducted on all specimens with gastrointestinal polyps referred to the pathology Laboratories at ElRajhy hospital and surgical pathology lab in Assuit University Hospital during the period from January 2022 to December 2024 after approval of the committee of ethics of scientific research in Faculty of Medicine in Assuit University. The data will be collected from registers, medical files and reports from pathological department of Assiut University Hospital.Slides will be reviewed with Haematoxylin-Eosin stain to determinethe type of the polyps.

You may not qualify if:

• Patients with insufficient data were excluded

Sponsors & Collaborators

• Assiut University: lead

Related Links

• D.Y. Park et al.Arch Pathol Lab Med(2008)
• Nomenclature Abstract for Fulvimonas Mergaert et al. 2002
• Colitides: diagnostic challenges and a pattern based approach to differential diagnosis
• Assarzadegan N, Montgomery E. Gastric polyps. Diagn Histopathol. 2017;23(12):521-9.

MeSH Terms

Conditions

Gastrointestinal Neoplasms

Condition Hierarchy (Ancestors)

Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Resident pathology doctor

Study Record Dates

• First Submitted: April 8, 2025
• First Posted: April 16, 2025
• Study Start: September 1, 2025
• Primary Completion (Estimated): November 1, 2026
• Study Completion (Estimated): December 1, 2026
• Last Updated: April 16, 2025

Record last verified: 2025-04