Housing, Environment, And Living Conditions for Transformed Health

NCT06925373 | Recruiting DMC

• 2 other identifiers: IRB-3000134001U01NR021591
• Study Type: interventional
• Target: 460
• Locations: 1 country
• Sites: 1

Brief Summary

This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each approach. STUDY 1: The study will assess the effects of public housing and neighborhood environment (built and social) improvements on health-related behaviors, psychosocial and physiologic stress, and self-reported and physiological markers of lung health and chronic disease. STUDY 2: The study will determine whether indoor air purification can positively impact lung health in public housing sites not undergoing housing renovation, comparing a site near industrial pollution vs one less contaminated.

Conditions

Lung Diseases; Chronic Disease

Keywords

Lung Health; Chronic Disease

Outcome Measures

Primary Outcomes (3)

• Change in Patient-Reported Outcomes Measurement Information System (PROMIS-10) Global Health

  A self-reported measure of physical, mental, and social health. 10 item questionnaire T-score metric from zero to 100 where higher T-scores indicate better health.

  Baseline, 12 months, 24 months

• Change in Allostatic load

  Measure of cumulative stress burden as the number of 10 indicators above a threshold: (1) serum albumin \<3.8 g/dL, (2) C Reactive Protein (CRP) \>3 mg/L, (3) High-Density Lipoprotein (HDL) \<40 mg/dL, (4) total cholesterol ≥240 mg/dL, (5) heart rate ≥90 beats/min, (6) systolic Blood Pressure (BP) ≥140 mmHg, (7) diastolic BP ≥90 mmHg, (8) serum creatinine ≥1.3 mg/dL, (9) Blood Urea Nitrogen (BUN) ≥18 mg/dL, and (10) waist circumference \>88 cm in women, \>102 cm in men.

  Baseline, 12 months

• Change in Indoor Air Quality

  Particulate matter (PM2.5). Measures particles in the air that are 2.5 micrometers or smaller in diameter.

  Baseline, 6 months, 12 months (Study 2 only)

Secondary Outcomes (1)

• The percentage change in FEV1/FVC

  Baseline, 6 months, 12 months (Study 2 only)

Study Arms (4)

Elyton Village Community

ACTIVE COMPARATOR

Participants will receive improved neighborhood environment (built and social) and indoor air purification.

Other: Indoor Air Purification; Other: Neighborhood Improvements

Southtown Court Community

ACTIVE COMPARATOR

Participants will receive new public housing.

Other: Housing Improvements

Smithfield Court Community

ACTIVE COMPARATOR

Participants will receive new public housing and improved neighborhood environment (built and social).

Other: Neighborhood Improvements; Other: Housing Improvements

Collegeville Community

ACTIVE COMPARATOR

Participants will receive indoor air purification.

Other: Indoor Air Purification

Interventions

Indoor Air Purification OTHER

An indoor air purifier with a dual HEPA/activated carbon filter, a usage tracker, and an indoor air quality monitor will be installed in public housing residences.

Also known as: Coway Airmega 400

Collegeville Community; Elyton Village Community

Neighborhood Improvements OTHER

Improved built environment (green space, sidewalks, street lights) and social environment (educational and workforce development programs, wrap-around social services, Internet access).

Elyton Village Community; Smithfield Court Community

Housing Improvements OTHER

High-quality public housing

Smithfield Court Community; Southtown Court Community

Eligibility Criteria

• Age: 18 Years - 89 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Adults age 18 years and older
• English speaking
• Residents of one of 4 public housing site in Birmingham, Alabama

You may not qualify if:

• Individuals who are not 18 years or older
• Do not speak English
• Do not meet the residency criteria

Sponsors & Collaborators

• University of Alabama at Birmingham: lead
• National Institute of Nursing Research (NINR): collaborator

Study Sites (1)

UAB Lung Health Center

Birmingham, Alabama, 35233, United States

RECRUITING

MeSH Terms

Conditions

Lung Diseases; Chronic Disease

Condition Hierarchy (Ancestors)

Respiratory Tract Diseases; Disease Attributes; Pathologic Processes; Pathological Conditions, Signs and Symptoms

Study Officials

• Gabriela R Oates, PhD

  University of Alabama at Birmingham (UAB)

  PRINCIPAL INVESTIGATOR

Central Study Contacts

Gabriela R Oates, PhD

CONTACT

205-996-5689; goates@uab.edu

Joy R Ledvina, Program Director, MBA

CONTACT

205-975-7852; jrledvina@uabmc.edu

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: PREVENTION
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 11, 2025
• First Posted: April 13, 2025
• Study Start: June 18, 2025
• Primary Completion (Estimated): July 1, 2028
• Study Completion (Estimated): July 1, 2028
• Last Updated: June 25, 2025

Record last verified: 2025-06

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, ICF
• Time Frame: Data will be available beginning 12 months and ending 36 months after publication.
• Access Criteria: Data will be available to investigators who submit an approved proposal and sign a Data Use Agreement. Proposals should be submitted to goates@uab.edu.

Locations

US (1)