Molecular Epidemiology of Enteroviruses Detected at the Virology Laboratory of Brest University Hospital During the Period 2018-2024: Retrospective Analysis of an Atypical Meningitis Epidemic in 2024 (BrEcho9Men)

NCT06922474 | Active Not Recruiting

• 1 other identifier: 29BRC25.0054 - BrEcho9Men
• Study Type: observational
• Target: 270
• Locations: 1 country
• Sites: 1

Brief Summary

This study is being done to learn more about enterovirus infections detected in the cerebrospinal fluid of patients at CHU de Brest. Researchers will analyze medical records and laboratory data collected between 2018 and 2024. They will look at how these infections present in patients, and whether a specific virus type, called Echo-9, may be associated with different clinical features or represent an emerging variant.

Conditions

Enterovirus Infections; Meningitis, Viral; Meningitis Enterovirus; Echovirus 9

Keywords

Echovirus 9; Enterovirus; Viral meningitis; Molecular epidemiology; Phylogenetic analysis; RT-PCR; Retrospective study; Surveillance; France; outbreak; Emerging variant; France epidemiology

Outcome Measures

Primary Outcomes (1)

• Phylogenetic analysis of Echo-9 strains detected between 2018 and 2024

  Molecular characterization and phylogenetic comparison of Echo-9 strains detected at CHU de Brest and throughout France between January 1, 2018 and December 31, 2024, to identify a possible emerging variant.

  January 1, 2018 to December 31, 2024

Secondary Outcomes (3)

• Temporal distribution of enterovirus infections documented at CHU de Brest

  January 1, 2018 to December 31, 2024

• Clinical characteristics of enterovirus-positive CSF cases

  January 1, 2018 to December 31, 2024

• Biological characteristics of enterovirus-positive CSF samples

  January 1, 2018 to December 31, 2024

Eligibility Criteria

• Age: 0 Days - 100 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients with a cerebrospinal fluid sample positive for enterovirus by RT-PCR performed at the virology laboratory of CHU de Brest between 2018 and 2024. This includes patients managed at CHU de Brest as well as at partner hospitals in Finistère (France) whose samples were processed centrally.

You may qualify if:

• Cerebrospinal fluid (CSF) sample positive for enterovirus by RT-PCR between January 1, 2018 and December 31, 2024 , performed at the virology laboratory of CHU de Brest.
• No documented opposition to the use of medical data for research purposes.

You may not qualify if:

• Patients under legal protection (guardianship, curatorship, etc.)
• Refusal to participate in the study

Sponsors & Collaborators

• University Hospital, Brest: lead

Study Sites (1)

Chu Brest

Brest, 29200, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

Clinical specimens tested positive for enteroviruses by RT-PCR will be retained. These include cerebrospinal fluid (CSF), throat swabs, stool samples, and nasopharyngeal swabs collected as part of routine care.

MeSH Terms

Conditions

Enterovirus Infections; Meningitis, Viral

Condition Hierarchy (Ancestors)

Picornaviridae Infections; RNA Virus Infections; Virus Diseases; Infections; Central Nervous System Viral Diseases; Central Nervous System Infections; Central Nervous System Diseases; Nervous System Diseases; Meningitis; Neuroinflammatory Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: April 3, 2025
• First Posted: April 10, 2025
• Study Start: March 1, 2025
• Primary Completion: October 31, 2025
• Study Completion: October 31, 2025
• Last Updated: April 10, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL
• Time Frame: Data will be available beginning three years and ending fifteen years following the final study report completion
• Access Criteria: Data access requests will be reviewed by the internal committee of Brest UH. Requestors will be required to sign and complete a data access agreement

Locations

FR (1)