NCT06919263

Brief Summary

Adolescent non-users of e-cigarettes and cannabis (N = 1,462) participated in the in-class survey-based experiment. They were randomly shown 3 pairs of images featuring influencers promoting e-cigarettes alongside cannabis, (experimental group), or no-substance use or display (placebo treatment), or e-cigarette promotion alone (control). After viewing each pair of images, participants rated perceptions of influencer credibility (i.e., honesty, trustworthiness, knowledge) on the scale of 0 (e.g., dishonest) to 100 (honest). Susceptibility to use e-cigarettes was assessed after participants viewed all the images. These outcomes were then compared among participants who perceived influencers as credible and those who perceived influencers as non-credible.

Trial Health

87
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
1,462

participants targeted

Target at P75+ for not_applicable

Timeline
Completed

Started Sep 2023

Shorter than P25 for not_applicable

Geographic Reach
1 country

1 active site

Status
completed

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

September 25, 2023

Completed
2 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

November 30, 2023

Completed
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

November 30, 2023

Completed
1.3 years until next milestone

First Submitted

Initial submission to the registry

March 20, 2025

Completed
20 days until next milestone

First Posted

Study publicly available on registry

April 9, 2025

Completed
Last Updated

April 9, 2025

Status Verified

March 1, 2025

Enrollment Period

2 months

First QC Date

March 20, 2025

Last Update Submit

April 4, 2025

Conditions

Outcome Measures

Primary Outcomes (2)

  • Perceptions of influencer credibility

    Perceptions of influencer credibility (i.e., honesty, trustworthiness, knowledge) were assessed using a 0 (e.g., dishonest) -100 (e.g., honest) scale that has been validated in prior research.

    assessed during the ~ 30-minute experiment, immediately after each of the three pairs of influencer images

  • Susceptibility to use e-cigarettes

    Susceptibility to use e-cigarettes was measured using the validated three-item scale adapted from Population Assessment of Tobacco and Health (PATH), and combined into one variable (α=0.93). Consistent with prior research, the measure was dichotomized with responses "definitely not" to all items being coded as "not susceptible" and responses "probably not," "probably yes", or "definitely yes" being coded as "susceptible."

    one-time assessment after the experimental exposure (immediately post-treatment)

Study Arms (3)

Experimental group

ACTIVE COMPARATOR

Images featuring influencers promoting e-cigarettes alongside cannabis

Behavioral: Influencer marketing

Placebo group

ACTIVE COMPARATOR

Images featuring neutral profiles of influencers not using or displaying any substances

Behavioral: Influencer marketing

Control

ACTIVE COMPARATOR

Images featuring influencers promoting e-cigarettes alone

Behavioral: Influencer marketing

Interventions

Participants viewed survey-imbedded promotional images featuring influencers

ControlExperimental groupPlacebo group

Eligibility Criteria

Age16 Years - 17 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17)

You may qualify if:

  • English fluency,
  • Current California resident.

You may not qualify if:

  • Not meeting these criteria:
  • English fluency,
  • Current California resident.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

University of Southern California

Los Angeles, California, 90032, United States

Location

MeSH Terms

Conditions

Vaping

Condition Hierarchy (Ancestors)

SmokingBehavior

Study Officials

  • Gina Klemm

    University of Southern California

    STUDY DIRECTOR

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
NONE
Purpose
OTHER
Intervention Model
FACTORIAL
Model Details: Images featuring influencers promoting e-cigarettes alongside cannabis products
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

March 20, 2025

First Posted

April 9, 2025

Study Start

September 25, 2023

Primary Completion

November 30, 2023

Study Completion

November 30, 2023

Last Updated

April 9, 2025

Record last verified: 2025-03

Locations