Renal Perfusion and the Development of AKI Following Traumatic Injury
PERTAKI
1 other identifier
observational
20
1 country
1
Brief Summary
Acute kidney injury (AKI) is a complication of traumatic haemorrhagic shock (THS) and together these conditions increase mortality risk. Although septic shock patients who develop severe AKI are known to develop hypoperfusion of the renal cortex, little is known regarding intra-renal perfusion changes in THS. The aim of the current study is to investigate the effects of THS on renal microcirculatory perfusion.
Trial Health
Trial Health Score
Automated assessment based on enrollment pace, timeline, and geographic reach
participants targeted
Target at below P25 for all trials
Started Apr 2024
Typical duration for all trials
1 active site
Health score is calculated from publicly available data and should be used for screening purposes only.
Trial Relationships
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Study Timeline
Key milestones and dates
Study Start
First participant enrolled
April 13, 2024
CompletedFirst Submitted
Initial submission to the registry
April 1, 2025
CompletedFirst Posted
Study publicly available on registry
April 8, 2025
CompletedPrimary Completion
Last participant's last visit for primary outcome
January 1, 2026
CompletedStudy Completion
Last participant's last visit for all outcomes
July 1, 2026
ExpectedApril 8, 2025
March 1, 2025
1.7 years
April 1, 2025
April 1, 2025
Conditions
Outcome Measures
Primary Outcomes (1)
Cortical mean transit time (mTT) measured in seconds
Contrast enhanced ultrasound measure of renal cortical tissue blood flow
Measured at enrollment, +24 hours and + 48 hours
Secondary Outcomes (3)
Cortical perfusion index (PI) measured in arbitrary units
Measured at enrollment, +24 hours and + 48 hours
Cortical wash in rate (WiR) measured in arbitrary units
Measured at enrollment, +24 hours and + 48 hours
Urinary oxygen tension (pO2) across 24 hours study period measured in millimetres of mercury (mmHg)
Across 48 hour study period
Other Outcomes (3)
Perfused vessel density (PVD) measured in millimetres per square millimetre
Measured at enrollment, +24 hours and + 48 hours
Microvascular flow index (MFI) (unitless score from 0 to 3 where 3 is the value see in health)
Measured at enrollment, +24 hours and + 48 hours
Syndecan 1, angiopoietin 1 & 2, Interleukin 6 & 8 (IL-6, IL-8) and tissue necrosis factor (TNF). All measured in nanograms per millilitre (ng/ml)
Measured at enrollment and + 48 hours
Study Arms (1)
Traumatic haemorrhagic shock
Interventions
Ultrasound measures: contrast enhanced ultrasound (CEUS) of the kidney, venous excess ultrasound (VExUS), echocardiography
Sublingual incident dark field (IDF) videomicroscopy
Eligibility Criteria
Patients admitted to critical care with traumatic haemorrhagic shock who fulfill the inclusion and do no meet any exclusion criteria.
You may qualify if:
- Age \> 18 years
- Within 24 hours of ICU admission following traumatic injury
- Received any blood products during initial resuscitation
- Lactate \> 2 mmol/l at any stage prior to study enrolment
You may not qualify if:
- Known intolerance to Sonovue or any other ultrasound contrast agent
- Patients with un-survivable injuries / not expected to survive 24 hours in whom the intent of treatment is palliative
- Known CKD 4 or end stage renal failure
- Pregnancy
Contact the study team to confirm eligibility.
Sponsors & Collaborators
Study Sites (1)
King's College Hospital
London, SE5 9RS, United Kingdom
Biospecimen
Plasma / serum / urine
MeSH Terms
Conditions
Interventions
Condition Hierarchy (Ancestors)
Intervention Hierarchy (Ancestors)
Central Study Contacts
Study Design
- Study Type
- observational
- Observational Model
- COHORT
- Time Perspective
- PROSPECTIVE
- Sponsor Type
- OTHER
- Responsible Party
- SPONSOR
Study Record Dates
First Submitted
April 1, 2025
First Posted
April 8, 2025
Study Start
April 13, 2024
Primary Completion
January 1, 2026
Study Completion (Estimated)
July 1, 2026
Last Updated
April 8, 2025
Record last verified: 2025-03