Analysis of Peripheral Serotonin Levels in a Control Cohort

NCT06910774 | Completed

• 1 other identifier: 2024/0033
• Study Type: observational
• Target: 100
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to measure serotonin levels in in a control cohort. The main question aims to determine the mean serum serotonin level in a cohort of adult controls, based on age and sex. This will allow for the establishment of reference values. We will also measure the different metabolites of tryptophan. These measurements will be performed on residual blood samples in the laboratory, after blood collection carried out as part of routine care. Thus, patients will not need to undergo an additional blood draw.

Conditions

No Condition : to Establish Reference Serum Serotonin Levels in a Control Cohort

Keywords

serotonin (5-HT); tryptophan; control cohort; age; sex; iron status

Outcome Measures

Primary Outcomes (1)

• Serotonin

  Measurement of serotonin levels in serum (HPLC: high performance liquid chromatography)

  at day 0

Secondary Outcomes (1)

• Tryptophan metabolites

  at day 0

Study Arms (1)

control cohort

* Adult patients aged ≥ 18 years * Who have undergone a blood draw at CHSF during the recruitment period * With hemoglobin, white blood cell, and platelet counts within the laboratory's normal ranges * With a C-reactive protein (CRP) level \< 30 mg/L

Other: Dosage of serotonin and tryptophan metabolites levels in serum

Interventions

Dosage of serotonin and tryptophan metabolites levels in serum OTHER

These measurements will be performed on residual blood samples in the laboratory, after blood collection carried out as part of routine care. Patients will not need to undergo an additional blood draw.

control cohort

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

The study population is a control cohort. We will include adult patients aged 18 years or older who have undergone a blood draw at CHSF during the recruitment period. Eligible participants must have hemoglobin, white blood cell, and platelet counts within the laboratory's normal ranges, and a C-reactive protein (CRP) level below 30 mg/L.

You may qualify if:

• Adult patients aged ≥ 18 years
• Who have undergone a blood draw at CHSF during the recruitment period
• With hemoglobin, white blood cell, and platelet counts within the laboratory's normal ranges
• With a C-reactive protein (CRP) level \< 30 mg/L

You may not qualify if:

• Patients informed about the study who decline participation
• Patients with a current diagnosis or history of psychiatric disorders
• Patients on antidepressants or narcotics at the time of sampling

Sponsors & Collaborators

• Centre Hospitalier Sud Francilien: lead

Study Sites (1)

Centre Hospitalier Sud Francilien

Corbeil-Essonnes, France, 91110, France

Location

Biospecimen

Retention: SAMPLES WITHOUT DNA

The remaining blood samples from the samples taken as part of the treatment will be the subject of a biological collection

MeSH Terms

Conditions

Coitus

Condition Hierarchy (Ancestors)

Sexual Behavior; Behavior

Study Officials

• Guillemette FOUQUET, MD

  Centre Hospitalier Sud Francilien

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 28, 2025
• First Posted: April 4, 2025
• Study Start: June 23, 2025
• Primary Completion: November 16, 2025
• Study Completion: November 16, 2025
• Last Updated: December 30, 2025

Record last verified: 2025-12

Data Sharing

• IPD Sharing: Will not share

Locations

FR (1)