NCT06907693|Completed
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Sponsor study identifier
observational
7
1 country
1
Study Start
March 14, 2025
Actual (reported)Primary Completion
December 4, 2025
Actual (reported)Study Completion
April 9, 2026
Actual (reported)Explore the impact of drug candidate CS1 on pathological vascular remodeling of small pulmonary arteries in the disease pulmonary arterial hypertension (PAH). This sub-study for CS1-004 aims to utilize FRI, an innovative, non-invasive imaging technology to visualize how long-term use of CS1 influences structural changes in pulmonary arteries. This sub-study seeks to provide valuable insights into the potential of CS1 to transform PAH treatment in some patients enrolled in the Expanded Access Program (CS1-004).
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 9, 2026
Actual (reported)Click on a node to explore related trials.
Some registry-reported names shown below are not yet linked in this graph.
Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 14, 2025
Actual (reported)March 27, 2025
Actual (reported)April 2, 2025
Actual (reported)December 4, 2025
Actual (reported)April 9, 2026
Actual (reported)Ratio of BV5A to BV10A
Change from baseline to month 12 in the ratio BV5A/BV10A
From baseline CT scan to 12 month CT scan
Ratio of BV5A to BV5APR
From baseline CT scan to 12 month CT scan
Ratio of BV5A to BV5APRA
From baseline CT scan to 12 month CT scan
All subjects in this study will undergo CT pulmonary angiography scans at baseline (+/- 2 months from start of drug therapy), 4 months and 12 months.
Computed tomography (CT) pulmonary angiography scan of the chest with IV contrast
Registry-reported names are shown in full. Names without a link have not yet been matched to a Syfrah profile.
Participation in the CS1-004 clinical trial at Prisma Health-Upstate
Prisma Health
Greenville, South Carolina, 29605, United States
1. US EPA O. Frequent Questions: Radiation in Medicine. www.epa.gov. Published December 4, 2023. https://www.epa.gov/radiation/frequent-questions-radiation-medicine
7 participants (actual enrollment reported by the registry).
First Submitted
March 27, 2025
First Posted
April 2, 2025
Study Start
March 14, 2025
Actual (reported)Home Rehabilitation Improves Cardiac Effort in Pulmonary Arterial Hypertension
Contact the study team to confirm eligibility.
Primary Completion
December 4, 2025
Actual (reported)Study Completion
April 9, 2026
Actual (reported)Last Updated
April 13, 2026
Record last verified: 2026-04
Download the complete ClinicalTrials.gov record imported by Syfrah, including fields not shown in this page. The registry may contain a newer revision.
Source: ClinicalTrials.gov.
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