The Effect of Salpingectomy Operation on Ovarian Reserve

NCT06903650 | Completed

• 1 other identifier: SOORAMHODU
• Study Type: observational
• Target: 31
• Locations: 1 country
• Sites: 1

Brief Summary

This study aimed to evaluate the effect of salpingectomy operation on ovarian reserve. Ovarian reserve was evaluated by measuring anti-mullerian hormone levels from serum samples taken from the patients before the operation and 6 weeks after the operation. Ovarian doppler flow were evaluated by measuring the ovarian artery pulsatility index with transvaginal ultrasonography preoperatively, postoperative days 2 and postoperative weeks 6 . In our study, it was determined that ovarian functions may be negatively affected in the acute period after salpingectomy operation.

Conditions

Ovarian Insufficiency

Keywords

Salpingectomy; Ovarian Reserve; Anti-Mullerian Hormone; Doppler Ultrasonography

Outcome Measures

Primary Outcomes (3)

• right ovarian arter pı

  rate of 0,87/ 0,84/ 0,76

  perioperative, postoperative days 2 , postoperative weeks 6

• left ovarian arter pı

  rate of 0,89/ 0,79/ 0.80

  perioperative, postoperative days 2, postoperative weeks 6

• AMH levels

  Concentration of 1 ng/mL / 0,79 ng/mL

  perioperative-postoperative weeks 6

Study Arms (3)

perioperative ovarian arter pulsatility index(PI)(right and left), perioperative AMH levels

Procedure: bilateral salpingectomy, ovarian arter doppler ultrasonography

postoperative days 2 ovarian arter pulsatility index (PI) (right and left)

Procedure: bilateral salpingectomy, ovarian arter doppler ultrasonography

postop. weeks 6 ovarian arter pulsatility index(PI)(right and left), postop. weeks 6 AMH levels

Procedure: bilateral salpingectomy, ovarian arter doppler ultrasonography

Interventions

bilateral salpingectomy, ovarian arter doppler ultrasonography PROCEDURE

The effect of salpingectomy operation on ovarian reserve

perioperative ovarian arter pulsatility index(PI)(right and left), perioperative AMH levels; postop. weeks 6 ovarian arter pulsatility index(PI)(right and left), postop. weeks 6 AMH levels; postoperative days 2 ovarian arter pulsatility index (PI) (right and left)

Eligibility Criteria

• Age: 37 Years - 45 Years
• Sex: female
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Serum samples will be separated from routine blood samples taken from patients who apply to the outpatient clinic and will undergo salpingectomy within the indication, during perioperative preparation and at the 6th week postoperatively, after patient consent is obtained. This serum sample will be taken into an Eppendorf tube and kept at -40˚C for later AMH levels to be studied. Ovarian artery pulsatility index values measured during the patient's perioperative and postoperative routine ultrasonographic examination and weeks 6 postoperative control will be recorded.

You may qualify if:

• Women between the ages of 37-45 with continuing menstrual cycles (37 and 45 included)
• Patients who will undergo uterine surgery for benign reasons or who will undergo salpingectomy only due to hydrosalpinx, ectopic pregnancy, tubo-ovarian abscess
• Patients who have not had ovarian surgery before
• Those without menopause and premature ovarian failure
• Patients who accept the study

You may not qualify if:

• Age younger than 37 or older than 45
• Those who want to withdraw from the study
• Those who do not come for follow-up examination
• Use of drugs that affect ovarian reserve
• Any surgical procedure performed on the ovaries during the operation
• No menstrual bleeding in the last year
• Patients who received radiotherapy and hormonal therapy within 3 months before surgery

Sponsors & Collaborators

• Dokuz Eylul University: lead

Study Sites (1)

Dokuz Eylul University School of Medicine

Izmir, 35000, Turkey (Türkiye)

Location

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Principal Investigator

Study Record Dates

• First Submitted: March 21, 2025
• First Posted: March 31, 2025
• Study Start: October 27, 2020
• Primary Completion: March 3, 2021
• Study Completion: June 5, 2021
• Last Updated: April 3, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)