Cannabis in Postoperative Pain Management

NCT06903624 | Completed DMC

• 1 other identifier: 005-2025
• Study Type: observational
• Target: 70,000
• Locations: 0 countries
• Sites: N/A

Brief Summary

Postoperative pain management is critical for surgical recovery, affecting patient outcomes, hospitalization duration, and quality of life. Variability in pain perception and medication needs among surgical patients poses a challenge in clinical practice. Identifying predictive factors for pain severity and analgesic use could enhance personalized pain management strategies. Cannabis, containing cannabinoids with analgesic and anti-inflammatory properties, has garnered attention as a potential pain management option for surgical patients. The effectiveness of cannabis varies, depending on surgery type, severity, and individual pain tolerance. Some studies suggest cannabis users may experience heightened pain sensitivity and require more analgesics, while others highlight its potential to reduce opioid use. Despite growing interest, the use of cannabis in surgery remains controversial due to a lack of large-scale clinical trials evaluating its safety and efficacy in this setting. Some research indicates cannabis use could lower pain levels post-surgery and reduce opioid needs. However, other studies raise safety concerns, and conflicting findings have yet to establish its role conclusively. Given these uncertainties, healthcare professionals must carefully monitor cannabis use in surgical patients. Patients should inform providers of any cannabis use before surgery to ensure appropriate pain management and minimize risks. This study aims to analyze pain intensity and analgesic usage patterns across various surgeries using real-world medical data. Machine learning models will predict high analgesic needs, focusing on cannabis users. This research seeks to optimize postoperative pain treatment and personalize clinical strategies.

Conditions

Postoperative Pain

Keywords

Cannabis; Postoperative pain; Analgesics; Opioids

Outcome Measures

Primary Outcomes (1)

• Pain Intensity

  To assess the impact of cannabis use on postoperative pain intensity (measured using the To assess the impact of cannabis use on postoperative pain intensity (measured using the Visual Analog Scale, VAS in a scale from 0 -no pain- to 10 -worst pain possible-)

  7 days

Secondary Outcomes (1)

• Analgesic Consumption

  7 days

Study Arms (2)

Non cannabis users

Patients that underwent surgical procedures

Chronic cannabis users

Patients that use cannabis due to medical conditions causing chronic pain and underwent surgical procedure.

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

All patients that underwent painfull surgical procedures will be cosidered in the study.

You may qualify if:

• Patients aged 18 and over.
• Patients who underwent surgery under general anesthesia.

You may not qualify if:

• Minimally painful surgical procedures, including wrist and ankle tendon surgeries, minor rectal surgeries (e.g., fistula repair, rectal polyp removal), and minor gynecological procedures (e.g., vaginal procedures, transvaginal tape \[TVT\] insertion and transurethral procedures).
• Surgeries associated with potential neurological complications, such as craniotomy.
• Procedures involving percutaneous stent placement, including ureteral stent insertion.
• Incomplete pain assessment records
• Patients with severe cognitive impairments, affecting their ability to accurately report pain levels.
• Patients unable to express VAS scale.

Sponsors & Collaborators

• Assuta Medical Center: lead

MeSH Terms

Conditions

Pain, Postoperative; Marijuana Abuse

Condition Hierarchy (Ancestors)

Postoperative Complications; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Pain; Neurologic Manifestations; Signs and Symptoms; Substance-Related Disorders; Chemically-Induced Disorders; Mental Disorders

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Medicine Doctor

Study Record Dates

• First Submitted: March 24, 2025
• First Posted: March 31, 2025
• Study Start: January 1, 2016
• Primary Completion: February 25, 2025
• Study Completion: March 24, 2025
• Last Updated: April 3, 2025

Record last verified: 2025-03