Precision Sleep Medicine

NCT06903481 | Completed

• 1 other identifier: 2025-00175; kt24Herrmann
• Study Type: observational
• Target: 1,055
• Locations: 1 country
• Sites: 2

Brief Summary

This retrospective observational study aims to characterize the prevalence and clinical features of obstructive sleep apnea (OSA) phenotypes and develop a rater-independent algorithm for automated OSA phenotyping, improving diagnosis and personalized treatment.

Conditions

Obstructive Sleep Apnea

Keywords

Polysomnography (PSG) recordings

Outcome Measures

Primary Outcomes (1)

• Phenotype characterization

  To characterize the prevalence and clinical features of distinct obstructive sleep apnea (OSA) phenotypes in a large, diverse patient population, polysomnography (PSG) recordings from two publicly available National Sleep Research Resource data collections are analyzed and compared to datasets from the University Hospital Basel (USB) and University Children's Hospital Basel (UKBB) to assess generalizability.

  2025

Secondary Outcomes (1)

• Computer-aided phenotyping

  2025

Study Arms (2)

Adults

Adults who underwent polysomnography recordings at the University Hospital Basel in 2023.

Children and adolescents

Children and adolescents who underwent polysomnography recordings at the University Children's Hospital Basel between January 2022 to July 2024.

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Adults who underwent polysomnography recordings at the University Hospital Basel in 2023, as well as children and adolescents who underwent polysomnography recordings at the University Children's Hospital Basel between January 2022 and July 2024. All patients have signed the general consent of the university hospital (UBS), resp. The university children's hospital (UKBB).

You may qualify if:

• age 19 years and older (data from University Hospital Basel (USB))
• age 18 years or younger (data from University Children's Hospital Basel (UKBB))
• Epworth Sleepiness Scale (ESS) score available (USB only)
• Diagnosis available (e.g. Obstructive sleep apnea (OSA), Central Sleep Apnea (CSA), Cheyne Stokes Breathing (CSR), ...)
• signed written general consent

You may not qualify if:

• history of treatment of sleep apnea
• tracheostomy
• current home oxygen therapy
• decline to sign the written general consent, or absence of written general consent

Sponsors & Collaborators

• University Hospital, Basel, Switzerland: lead
• Rekonas GmbH: collaborator

Study Sites (2)

University Children's Hospital Basel

Basel, Canton of Basel-City, 4031, Switzerland

Location

University Hospital Basel

Basel, Canton of Basel-City, 4031, Switzerland

Location

MeSH Terms

Conditions

Sleep Apnea, Obstructive

Condition Hierarchy (Ancestors)

Sleep Apnea Syndromes; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders; Nervous System Diseases

Study Officials

• Matthias Herrmann, Dr. med.

  University Hospital, Basel, Switzerland

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2025
• First Posted: March 30, 2025
• Study Start: January 1, 2022
• Primary Completion: July 31, 2024
• Study Completion: July 31, 2024
• Last Updated: March 30, 2025

Record last verified: 2025-03

Locations

CH (2)