PRevalence Of Transient Global Amnesia in Obstructive Sleep Apnea Syndrome

NCT06903026 | Recruiting

• 1 other identifier: 8781
• Study Type: observational
• Target: 250
• Locations: 1 country
• Sites: 1

Brief Summary

Amnesic stroke is an amnestic syndrome lasting less than 24 hours characterized by the occurrence of anterograde amnesia often associated with retrograde amnesia, the pathophysiology of which is still poorly understood at present. A recent study on a small sample size (N=29) highlighted an association between obstructive sleep apnea syndrome and amnesic stroke. Our study seeks to confirm or refute these results on a larger cohort (N=200-250). A better understanding of the pathophysiological processes involved would open up new therapeutic avenues.

Conditions

Transient Global Amnesia

Keywords

Transient Global Amnesia; Sleep apnea syndrome

Outcome Measures

Primary Outcomes (1)

• To assess the prevalence of obstructive sleep apnea syndrome in patients who have experienced an amnestic stroke.

  Presence or absence of obstructive sleep apnea syndrome reported by a witness present during the stroke.

  Within the last 2 years

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria.

You may qualify if:

• Adult patients seen for consultation in the Neuropsychology Department of Strasbourg University Hospital between March 1, 2015 and December 31, 2021 following an episode of amnestic stroke meeting the Hodges and Warlow criteria:
• The stroke must have been documented and reported by a competent witness present during the stroke.
• Anterograde amnesia during the stroke.
• Absence of vigilance, personality, and cognitive disorders other than memory disorders (aphasia, apraxia, etc.).
• Absence of focal neurological symptoms during the episode and its aftermath.
• Absence of epileptic manifestations.
• Resolution of the episode in less than 24 hours.
• Subjects who have not expressed opposition to the reuse of their data for scientific research purposes.

You may not qualify if:

• Patients who have expressed opposition to the retrospective reuse of their data for scientific research purposes.
• Patients with active epilepsy
• Patients with recent head trauma
• Patients with an MMS \< or equal to 25
• Subject under guardianship or curatorship
• Subject under judicial protection

Sponsors & Collaborators

• University Hospital, Strasbourg, France: lead

Study Sites (1)

Service de Neurologie - CHU de Strasbourg - France

Strasbourg, 67091, France

RECRUITING

MeSH Terms

Conditions

Amnesia, Transient Global; Sleep Apnea Syndromes

Condition Hierarchy (Ancestors)

Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Amnesia; Memory Disorders; Neurobehavioral Manifestations; Neurologic Manifestations; Signs and Symptoms; Pathological Conditions, Signs and Symptoms; Neurocognitive Disorders; Mental Disorders; Apnea; Respiration Disorders; Respiratory Tract Diseases; Sleep Disorders, Intrinsic; Dyssomnias; Sleep Wake Disorders

Central Study Contacts

Benjamin CRETIN, MD

CONTACT

33 3 88 12 86 34; benjamin.cretin@chru-trasbourg.fr

Study Design

• Study Type: observational
• Observational Model: CASE ONLY
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 24, 2025
• First Posted: March 30, 2025
• Study Start: March 17, 2023
• Primary Completion: December 1, 2025
• Study Completion: December 31, 2025
• Last Updated: March 30, 2025

Record last verified: 2025-03

Locations

FR (1)