Seroprevalence and Vaccination Rate of Hepatitis B Virus and Varicella-zoster Virus Among Medical Students Under Immunizing Program

NCT06901362 | Completed

• 1 other identifier: MTU-EC-SA-0-159/67
• Study Type: observational
• Target: 401
• Locations: 1 country
• Sites: 1

Brief Summary

This study is a cross-sectional study. The study aims to determine the levels of immunity against hepatitis B virus and varicella-zoster virus in medical students.

Conditions

Healthy; Healthy Adult

Keywords

hepatitis B virus; varicella-zoster virus; vaccination; immunizing program; medical students

Outcome Measures

Primary Outcomes (2)

• The seroprevalence of hepatitis B virus

  The immunity level against the hepatitis B virus is assessed.

  From enrollment to the end of treatment at 6 months

• The seroprevalence of varicella-zoster virus

  The immunity level against varicella-zoster virus is assessed.

  From enrollment to the end of treatment at 6 months

Secondary Outcomes (2)

• The vaccination rate of hepatitis B virus

  From enrollment to the end of treatment at 6 months

• The vaccination rate of varicella-zoster virus

  From enrollment to the end of treatment at 6 months

Study Arms (1)

Medical students

Medical students aged 18 years or older

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Medical students aged 18 years or older are included.

You may qualify if:

• Medical students
• Age 18 years or older

You may not qualify if:

• Known cases of hepatitis B virus infection
• Known cases of varicella-zoster virus infection

Sponsors & Collaborators

• Thammasat University: lead
• Thammasat University Hospital: collaborator

Study Sites (1)

Narongkorn Saiphoklang

Pathum Thani, Changwat Pathum Thani, 12120, Thailand

Location

Related Publications (12)

• Techasathit W, Ratanasuwan W, Sonjai A, Sangsiriwut K, Anekthananon T, Suwanagool S. Vaccination against hepatitis B virus: are Thai medical students sufficiently protected? J Med Assoc Thai. 2005 Mar;88(3):329-34.

  PMID: 15962639 RESULT

• Baer G, Bonhoeffer J, Schaad UB, Heininger U. Seroprevalence and immunization history of selected vaccine preventable diseases in medical students. Vaccine. 2005 Mar 14;23(16):2016-20. doi: 10.1016/j.vaccine.2004.03.073.

  PMID: 15734076 RESULT

• Balbi O, Baldi S, Rizza S, Pietroiusti A, Perrone S, Coppeta L. Seroprevalence survey for Varicella among healthcare workers and medical students in Italy. Hum Vaccin Immunother. 2021 Feb 1;17(2):372-376. doi: 10.1080/21645515.2020.1771989. Epub 2020 Jul 9.

  PMID: 32643520 RESULT

• Pourakbari B, Shahbaznezhad L, Parvaneh N, Nikkhah S, Mahmoudi S, Teymuri M, Alyari A, Mamishi S. Seroepidemiology of Varicella Zoster Virus among children, adolescents and medical students in a referral children medical center, Tehran, Iran. Iran J Microbiol. 2012 Sep;4(3):136-8.

  PMID: 23066488 RESULT

• Sheek-Hussein M, Hashmey R, Alsuwaidi AR, Al Maskari F, Amiri L, Souid AK. Seroprevalence of measles, mumps, rubella, varicella-zoster and hepatitis A-C in Emirati medical students. BMC Public Health. 2012 Dec 5;12:1047. doi: 10.1186/1471-2458-12-1047.

  PMID: 23217121 RESULT

• Cardenas-Perea ME, Gomez-Conde E, Santos-Lopez G, Perez-Contreras I, Diaz-Orea MA, Gandara-Ramirez JL, Cruz Y Lopez OR, Marquez-Dominguez L, Sosa-Jurado F. Hepatitis B surface antibodies in medical students from a public university in Puebla, Mexico. Hum Vaccin Immunother. 2016 Jul 2;12(7):1857-62. doi: 10.1080/21645515.2016.1151587. Epub 2016 May 12.

  PMID: 27171749 RESULT

• Sartorelli P, Occhialini F, Miceli R, Pietronigro A, Bianciardi L, Salini C, Messina G. The seroprevalence of the hepatitis B virus in Italian medical students after 3 decades since the introduction of universal vaccination. Int J Occup Med Environ Health. 2022 Feb 15;35(1):75-80. doi: 10.13075/ijomeh.1896.01835. Epub 2021 Aug 25.

  PMID: 34448470 RESULT

• Tesfa T, Hawulte B, Tolera A, Abate D. Hepatitis B virus infection and associated risk factors among medical students in eastern Ethiopia. PLoS One. 2021 Feb 19;16(2):e0247267. doi: 10.1371/journal.pone.0247267. eCollection 2021.

  PMID: 33606777 RESULT

• Rathi A, Kumar V, Majhi J, Jain S, Lal P, Singh S. Assessment of knowledge, attitude, and practices toward prevention of hepatitis B infection among medical students in a high-risk setting of a newly established medical institution. J Lab Physicians. 2018 Oct-Dec;10(4):374-379. doi: 10.4103/JLP.JLP_93_18.

  PMID: 30498306 RESULT

• Yoda T, Katsuyama H. Analysis of antibody-negative medical students after hepatitis B vaccination in Japan. Hum Vaccin Immunother. 2021 Mar 4;17(3):852-856. doi: 10.1080/21645515.2020.1788309. Epub 2020 Aug 5.

  PMID: 32755433 RESULT

• Bianchi FP, Tafuri S, Larocca AMV, Germinario CA, Stefanizzi P. Long -term persistence of antibodies against varicella in fully immunized healthcare workers: an Italian retrospective cohort study. BMC Infect Dis. 2021 May 25;21(1):475. doi: 10.1186/s12879-021-06180-x.

  PMID: 34034659 RESULT

• Phattraprayoon N, Kakheaw J, Soonklang K, Cheirsilpa K, Ungtrakul T, Auewarakul C, Mahanonda N. Duration of Hepatitis B Vaccine-Induced Protection among Medical Students and Healthcare Workers following Primary Vaccination in Infancy and Rate of Immunity Decline. Vaccines (Basel). 2022 Feb 10;10(2):267. doi: 10.3390/vaccines10020267.

  PMID: 35214725 RESULT

Biospecimen

Retention: SAMPLES WITHOUT DNA

Blood samples for measuring immunity levels against the hepatitis B virus and varicella-zoster virus.

MeSH Terms

Conditions

Hepatitis B; Chickenpox

Condition Hierarchy (Ancestors)

Blood-Borne Infections; Communicable Diseases; Infections; Hepadnaviridae Infections; DNA Virus Infections; Virus Diseases; Hepatitis, Viral, Human; Hepatitis; Liver Diseases; Digestive System Diseases; Varicella Zoster Virus Infection; Herpesviridae Infections

Study Officials

• Narongkorn Saiphoklang, MD

  Thammasat University Faculty of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Study Record Dates

• First Submitted: March 22, 2025
• First Posted: March 28, 2025
• Study Start: April 1, 2025
• Primary Completion: August 31, 2025
• Study Completion: November 30, 2025
• Last Updated: December 23, 2025

Record last verified: 2025-04

Data Sharing

• IPD Sharing: Will share
• Shared Documents: STUDY PROTOCOL, SAP, CSR
• Time Frame: IPD and documents will be available for sharing immediately after publication for a period of 2 years.
• Access Criteria: All researchers will be able to access the IPD and supporting information via the repository website without restriction.

Locations

TH (1)