Comparison of the Efficacy of Erector Spinae Plane (ESP) and External Oblique and Rectus Abdominis Plane (EXORA) Blocks in Laparoscopic Cholecystectomy
Sponsor study identifier
interventional
56
1 country
1
Study Start
October 1, 2025
Actual (reported)Primary Completion
April 15, 2026
Actual (reported)Study Completion
April 15, 2026
Actual (reported)Patients undergoing laparoscopic cholecystectomy may experience moderate to severe postoperative pain. Effective postoperative analgesia enhances patient comfort and accelerates recovery. This study aims to compare the effects of Erector Spinae Plane (ESP) and External Oblique and Rectus Abdominis Plane (EXORA) blocks on postoperative pain management and analgesic consumption. The study is designed as a prospective, randomized, double-blind trial. Patients will be randomly assigned to groups, and both practitioners and evaluators will be blinded to group assignments. Our hypothesis is that the EXORA block will provide superior analgesia and require less analgesic consumption compared to the ESP block. The results will be assessed in terms of postoperative pain management, patient comfort, and additional analgesic requirements.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
April 15, 2026
Actual (reported)Click on a node to explore related trials.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
March 20, 2025
Actual (reported)March 28, 2025
Actual (reported)October 1, 2025
Actual (reported)April 15, 2026
Actual (reported)April 15, 2026
Actual (reported)Tramadol consumption
Total tramadol used in the first 12 and 24 hours postoperatively.
12 and 24 hours
Visual Analog Scale (VAS) for Pain Assessment
30 minutes, 2 hours, 4 hours, 8 hours, 12 hours, and 24 hours after surgery
Pinprick Sensory Block Test Results
10 minutes, 20 minutes, and 30 minutes after the block, and 30 minutes after surgery
The ESP block will be performed approximately 30 minutes before general anesthesia induction following sedation and standard monitoring. All block procedures will be conducted under sterile conditions, with skin preparation using dermol (%70 Isopropyl Alcohol, %2 Chlorhexidine Gluconate) and the ultrasound probe covered with a sterile drape.
The EXORA block will be performed 30 minutes before general anesthesia induction, following sedation and standard monitoring.
Experienced anesthesiologists with at least five years of expertise in regional anesthesia will perform the blocks under ultrasound guidance. A 4.0-12.0 MHz linear ultrasound probe (Affiniti 50; Philips) will be used. The ESP block will be applied at the T8 level on the right side, using an in-plane approach, while the patient is in a sitting position. The probe will be placed 2-3 cm lateral to the vertebra in a sagittal position to visualize the erector spinae muscle and transverse processes. A 22G, 100 mm block needle (Stimuplex® Ultra, Braun, Germany) will be advanced in a craniocaudal direction. The correct needle position will be confirmed by injecting 0.5-1 mL of isotonic NaCl and observing the spread via hydrodissection. Finally, 0.3 mL/kg of 0.25% bupivacaine will be administered, ensuring cranial and caudal spread of the local anesthetic.
Kütahya City Hospital
Kütahya, Turkey (Türkiye)
Aycan KURTARANGİL DOĞAN
Kütahya City Hospital
Ali Kaynak
Kütahya City Hospital
56 participants (actual enrollment reported by the registry).
First Submitted
March 20, 2025
First Posted
March 28, 2025
Study Start
October 1, 2025
Actual (reported)Nausea and Vomiting Score (NVS)
Within 24 hours after surgery
Ramsay Sedation Scale (RSS)
Within 24 hours after surgery
Additional Analgesic Consumption
Within 24 hours after surgery
Total Antiemetic Consumption
Within 24 hours after surgery
Experienced anesthesiologists with at least five years of expertise in regional anesthesia will administer the blocks under ultrasound guidance. A 4.0-12.0 MHz linear ultrasound probe will be placed laterally to the xiphoid process on the parasternal line in a sagittal position. The probe will be moved craniocaudally to identify the 6th rib and further advanced caudally to locate the 8th rib. Once the rectus abdominis muscle and 8th costal cartilage are identified, a 22G, 100 mm block needle will be used to administer 0.3 mL/kg of 0.25% bupivacaine. The correct spread of the local anesthetic will be confirmed via ultrasound.
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Primary Completion
April 15, 2026
Actual (reported)Study Completion
April 15, 2026
Actual (reported)Last Updated
September 18, 2026
Record last verified: 2026-09
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Source: ClinicalTrials.gov.
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