Multimodal Monitoring Study in Neuro Critical Care

NCT06900101 | Recruiting

• 1 other identifier: 713
• Study Type: observational
• Target: 500
• Locations: 1 country
• Sites: 1

Brief Summary

During the first week after an acute cerebral injury, neurologic clinical exam is often irrelevant, limited by sedation use or spontaneous consciousness disorders. Hence, neurological monitoring of brain oxygen consumption, metabolic disorders, electrical activity is used to follow and prevent delayed cerebral injuries. Among those instruments, numerous are often described: intra cranial pressure monitoring, brain tissue oxygen pressure monitoring, scalp electroencephalography, continuous electroencephalography and Near infrared Red Spectroscopy (NIRS). Even if the value of some of those technologies are well known, many remain part of a research domain. Here we will not only try to study the correlation between different cerebral autoregulation's index described in the scientific literature but also will we try to identify and describe EEG and cardiorespiratory changes during the first week following brain injury. The objective of this study is to investigate the pathophysiology of acute brain injury and explore potent biomarkers of multimodal monitoring during the first week following acute brain injury.

Conditions

Subarachnoidal Hemorrhage; Intacranial Hypertension; Acute Trauma Brain Injury

Outcome Measures

Primary Outcomes (1)

• Correlation between ORx and PRx

  Multimodal neuro monitoring is used from 1 to 15 days after the acute brain injury.

Study Arms (1)

Patients admitted in neurocritical care in Pierre Wertheimer hospital, following acute brain injury,

Other: Study the evolution and correlation between cerebral autoregulation index

Interventions

Study the evolution and correlation between cerebral autoregulation index OTHER

Objective n°1: Study the correlation between autoregulation index: The investigators will look for a correlation between several auroregulation index such as the PRx, ORx and Cox. Objective n°2: Evaluation and detection of EEG prognostic patterns: The investigators will look for quantitaive EEG changes during the early phase of acute brain injuries.

Patients admitted in neurocritical care in Pierre Wertheimer hospital, following acute brain injury,

Eligibility Criteria

• Age: 18 Years - 90 Years
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Probability Sample

Study Population

Patients hospitalized in neuro critical care, in Pierre Wertheimer hospital, for acute brain injury and monitored by MOBERG® system.

You may qualify if:

• \- Patients hospitalized in neurologic critical care in Wertheimer Hospital, Bron
• Monitored with the CNS MOBERG® monitoring system

You may not qualify if:

• \- Refusal to participate
• Patients under legal protection

Sponsors & Collaborators

• Hospices Civils de Lyon: lead

Study Sites (1)

Hopital Pierre Wertheimer

France, Bron, 69500, France

RECRUITING

Central Study Contacts

Dr Baptiste Balança

CONTACT

04 72 35 75 76; baptiste.balanca@chu-lyon.fr

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 21, 2025
• First Posted: March 28, 2025
• Study Start: January 1, 2020
• Primary Completion (Estimated): December 1, 2030
• Study Completion (Estimated): December 1, 2030
• Last Updated: March 28, 2025

Record last verified: 2025-03

Locations

FR (1)