A Study to Investigate Efficacy and Safety of Different Dose Regimen of Oral Cabazitaxel Tablet in Adult Participants with Prostate Cancer

NCT06890832 | Not Yet Recruiting Phase 2 FDA Drug

• 1 other identifier: 0128-23
• Study Type: interventional
• Target: 75
• Locations: 0 countries
• Sites: N/A

Brief Summary

A total of 75 participants will be enrolled in the study, with 25 participants allocated per intervention group. In Group 1, participant will take 50 mg cabazitaxel every week for 6 cycles (3 doses per cycle), 10 mg prednisone daily till the end of cycle 6. In Group 2, participant will take 100 mg cabazitaxel every week for 6 cycles (3 doses per cycle), 10 mg prednisone daily till the end of cycle 6. In Group 3, participant will take 200 mg cabazitaxel every 3 weeks for 6 cycles (1 doses per cycle), 10 mg prednisone daily till the end of cycle 6. The study comprises three phases: a 21-day screening phase, an 18-week intervention phase starting on Day 1 (baseline), and a post-intervention follow-up phase lasting up to 12 months from Day 1. The total duration of participation for each individual will be approximately one year. Key efficacy assessments include CT scans/MRI, bone scans, PSA, ALP, LDH, symptomatic skeletal events, and pain evaluations. Key safety assessments encompass the monitoring of adverse events (AEs), ECOG performance status, physical examinations, vital sign measurements, clinical laboratory tests, peripheral neuropathy evaluation, 12-lead ECG, and echocardiogram (ECHO) assessments. Pharmacokinetic parameters will also be evaluated.

Conditions

Metastatic Castration-resistant Prostate Cancer, MCRPC

Outcome Measures

Primary Outcomes (1)

• Radiographic progression-free survival (rPFS)

  12 months

Study Arms (3)

Arm 1

EXPERIMENTAL

Drug: 50 mg cabazitaxel

Arm 2

EXPERIMENTAL

Drug: 100 mg cabazitaxel

Arm 3

EXPERIMENTAL

Drug: 200 mg cabazitaxel

Interventions

50 mg cabazitaxel DRUG

50 mg cabazitaxel to be taken every week for 6 cycles (3 doses per cycle), 10 mg prednisone to be taken daily till end of cycle 6

Arm 1

100 mg cabazitaxel DRUG

100 mg cabazitaxel to be taken every week for 6 cycles (3 doses per cycle), 10 mg prednisone to be taken daily till end of cycle 6

Arm 2

200 mg cabazitaxel DRUG

200 mg cabazitaxel to be taken every 3-week for 6 cycles (1 dose per cycle), 10 mg prednisone to be taken daily till end of cycle 6

Arm 3

Eligibility Criteria

• Age: 18 Years+
• Sex: male
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Must sign an ICF indicating that the participant understands the purpose of, and procedures required for the study.
• Male participant ≥18 years of age at the time of signing the informed consent.
• Participant must have histological pathological, and/or cytological confirmation of adenocarcinoma of the prostate.
• Evidence of metastatic disease.
• Participant must be previously treated with a docetaxel-containing regimen (at least 3 cycles) for the treatment of prostate cancer (including locally confined inoperable disease that cannot be treated with definitive intent) and/or CRPC. Docetaxel administration in combination with androgen deprivation therapy (ADT) with or without next-generation AR-targeted therapy (abiraterone acetate, enzalutamide, or and next generation targeted agents Darolutamide, apalutamide) in metastatic hormone-sensitive disease is considered a prior docetaxel exposure.
• Progressive disease prior to screening by PSA or imaging per PCWG3 criteria during or following the direct prior line of therapy in the setting of medical or surgical castration.
• Participant must be taking ADT with a gonadotropin-releasing hormone (GnRH) analogue or bilateral orchiectomy (i.e., surgical or medical castration) confirmed by testosterone level ≤1.73 nmol/L (50 ng/dL) at the screening visit.
• Participant must be eligible for treatment with cabazitaxel per the locally approved prescribing information.
• ECOG PS grade of 0-2. ECOG PS 2 must be related to prostate cancer, not to other comorbidities.
• Estimated life expectancy of ≥6 months as assessed by the investigator.
• Participant has recovered from AEs (baseline or ≤ CTCAE Grade 1) due to prior anticancer therapy, unless AE(s) is either clinically nonsignificant or stable on supportive therapy or do not constitute a safety risk to the participant as determined by the investigator.
• Male participants are eligible to participate if they agree to the following during the intervention period and for at least 6 months after the last dose of study intervention:
• Must agree not to plan to father a child or donate sperm for the purpose of reproduction. PLUS, either of the following:
• Be abstinent from heterosexual intercourse as their preferred and usual lifestyle (abstinent on a long-term and persistent basis) and agree to remain abstinent OR
• Must agree to use contraception /barrier

You may not qualify if:

• Known allergies, hypersensitivity, or intolerance to any of the study interventions, or components/ excipients thereof (refer to the IB), or drug or other allergy that, in the opinion of the investigator, contraindicates participation in the study.
• Contraindications to the use of prednisone or medical ADT per locally approved prescribing information.
• Previous treatment with cabazitaxel in any setting.
• Had major surgical procedure or significant traumatic injury requiring general anaesthesia within 4 weeks or will not have fully recovered from surgical procedure prior to first dose of the study intervention; or has surgical procedure planned during the time the participant is expected to participate in the study.
• Prior isotope therapy, whole pelvic radiotherapy or radiotherapy to \>30% of bone marrow within 3 months prior to Baseline.
• Symptomatic peripheral neuropathy Grade ≥2 (National Cancer Institute Common Terminology Criteria \[NCI CTCAE\] v.5.0).
• Presence of hepatitis B surface antigen (HbsAg) at screening or within 3 months prior to first dose of investigational intervention.
• Positive hepatitis C antibody test result at screening or within 3 months prior to starting investigational intervention.
• Has known human immunodeficiency virus (HIV) seropositive status, or positive HIV antibody test at screening.
• History of malignancy (except for prostate cancer) within the past 5 years except if the participant has undergone potentially curative therapy with no evidence of that disease recurrence for at least 3 years since initiation of that therapy.
• Current or chronic history of liver disease. This includes \[but is not limited to hepatitis virus infections, drug- or alcohol-related liver disease, non-alcoholic steatohepatitis, autoimmune hepatitis, hemochromatosis, Wilson's disease, α-1 antitrypsin deficiency, primary biliary cholangitis, primary sclerosing cholangitis, or any other liver disease considered clinically significant by the investigator.
• Known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).
• Participant with clinically significant current or recent (within the past 3 months before randomization \[unless otherwise specified below\]) cardiac conditions.
• Known active CNS disease, except for treated stable asymptomatic CNS metastases.
• Known Leptomeningeal disease.

Sponsors & Collaborators

• Jina Pharmaceuticals Inc.: lead

MeSH Terms

Interventions

cabazitaxel

Study Design

• Study Type: interventional
• Phase: phase 2
• Allocation: RANDOMIZED
• Masking: NONE
• Purpose: TREATMENT
• Intervention Model: PARALLEL
• Sponsor Type: INDUSTRY
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 17, 2025
• First Posted: March 24, 2025
• Study Start: May 1, 2025
• Primary Completion (Estimated): December 1, 2026
• Study Completion (Estimated): June 1, 2027
• Last Updated: March 24, 2025

Record last verified: 2025-03