Predicting the Metabolic Biomarkers Associated With Injury in Athletes

NCT06888635 | Enrolling By Invitation

• 1 other identifier: XH-25-003
• Study Type: observational
• Target: 60
• Locations: 1 country
• Sites: 1

Brief Summary

For elite athletes, sports injuries significantly impede the further enhancement of their competitive performance. Consequently, the significance of preventing, detecting, and addressing potential injury issues has become increasingly critical. Currently, the comprehensive evaluation of athletes' physical function and condition primarily depends on a range of physiological, biochemical, and immunological indicators. However, these methods have progressively exposed their limitations. As an advanced bioinformatics technology, omics research demonstrates unique advantages. By leveraging multi-omics research and analysis, it is possible to more accurately observe the physiological and biochemical changes that athletes undergo during training and competition, as well as their regulatory mechanisms. This approach can provide practical data, identify biomarkers that can warn of potential injuries, and offer precise guidance for training monitoring and injury prevention. It also provides a foundation for developing diverse, precise, and personalized sports programs and rehabilitation plans.

Conditions

Sports Medicine

Keywords

sports medicine,; injury; biomarker; metabolite

Outcome Measures

Primary Outcomes (1)

• Number of participants with athletes with acute injuries

  Acute injuries are defined as the injuries of body tissues in a short period of time due to sudden external force or improper operation during sports.This injury usually has sudden and distinct traumatic features

  1year

Study Arms (3)

Acute Injury athletes

Athletes in sports, due to sudden external force or improper operation, resulting in body tissue damage in a short period of time. This injury usually has sudden and distinct traumatic features, and common types include: 1. Sprain: Joint due to excessive torsion or stretching, resulting in ligament damage. 2. Strain: An injury to a muscle or tendon caused by excessive stretching or contraction. 3. Contusion: A direct impact on the body part causes damage to the subcutaneous tissue, which may be accompanied by bruising. 4. Fracture: The bone is broken due to external force. 5. Dislocation: The joint is removed from its normal position due to external forces.

Healthy athletes

athletes with no acute injury in the last 3 months

Healthy

Healthy non-athlete population

Eligibility Criteria

• Age: 12 Years - 30 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17), Adult (18-64)
• Sampling Method: Non-Probability Sample

Study Population

Athletes in sports, due to sudden external force or improper operation, resulting in body tissue damage in a short period of time. This injury usually has sudden and distinct traumatic features, and common types include: 1. Sprain: Joint due to excessive torsion or stretching, resulting in ligament damage. 2. Strain: An injury to a muscle or tendon caused by excessive stretching or contraction. 3. Contusion: A direct impact on the body part causes damage to the subcutaneous tissue, which may be accompanied by bruising. 4. Fracture: The bone is broken due to external force. 5. Dislocation: The joint is removed from its normal position due to external forces.

You may qualify if:

• Age： Athletes 12-30 years old
• Acute injury during exercise: such as muscle, sprain, contusion, torn ligament, dislocation, fracture.

You may not qualify if:

• Athletes with serious cardio-cerebrovascular disease and abnormal liver and kidney function
• Recent use of drugs or supplements that affect metabolism.
• Pregnancy, lactation or special conditions that may affect metabolism.

Sponsors & Collaborators

• Xinhua Hospital, Shanghai Jiao Tong University School of Medicine: lead

Study Sites (1)

Department of Respiratory, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,China

Shanghai, 200092, China

Location

Biospecimen

Retention: SAMPLES WITH DNA

blood

MeSH Terms

Conditions

Wounds and Injuries

Study Officials

• Yue Zhang, Doctor

  Department of Respiratory, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: PROSPECTIVE
• Target Duration: 1 Year
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Study Record Dates

• First Submitted: March 2, 2025
• First Posted: March 21, 2025
• Study Start: April 16, 2025
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): December 31, 2027
• Last Updated: April 24, 2026

Record last verified: 2026-04

Locations

CN (1)