NCT06882798

Brief Summary

This study will test a model of providing treatment to Latinx/Hispanic youth, who experience suicidal thoughts and behavior, and their caregivers. An affirmative and culturally relevant treatment will be provided to all youth and half of the families will be assigned to the additional support of a community health worker (CHW). Youth symptoms and family engagement to treatment will be followed for nine months. The potential benefit of adding the CHW intervention will be assessed.

Trial Health

77
On Track

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Enrollment
150

participants targeted

Target at P75+ for not_applicable

Timeline
8mo left

Started Mar 2024

Typical duration for not_applicable

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

Click on a node to explore related trials.

Study Timeline

Key milestones and dates

Study Progress76%
Mar 2024Jan 2027

Study Start

First participant enrolled

March 28, 2024

Completed
12 months until next milestone

First Submitted

Initial submission to the registry

March 17, 2025

Completed
2 days until next milestone

First Posted

Study publicly available on registry

March 19, 2025

Completed
1.8 years until next milestone

Primary Completion

Last participant's last visit for primary outcome

January 1, 2027

Expected
Same day until next milestone

Study Completion

Last participant's last visit for all outcomes

January 1, 2027

Last Updated

March 19, 2025

Status Verified

March 1, 2025

Enrollment Period

2.8 years

First QC Date

March 17, 2025

Last Update Submit

March 17, 2025

Conditions

Keywords

Suicidal IdeationSuicide AttemptRandomized controlled trialadolescentsLatinxLatinaLatinoHispaniccognitive behavioral therapydepressive symptomscommunity health workers

Outcome Measures

Primary Outcomes (5)

  • Suicidal Ideation (SI)

    Suicidal ideation measured using the Suicide Ideation Questionnaire-Junior (SIQ-JR), a self-report instrument of 15 items that measures severity of suicidal ideation as a continuous variable with established normative, reliability, and validity data for clinical and non-clinical adolescent samples. The minimum score is 0 and the maximum 90. A higher score represents increased severity and frequency of suicidal thoughts.

    Change from baseline to 6 months and baseline to 9 months.

  • Suicide Attempts (SA)

    Actual and interrupted suicide attempts (yes or no) using the Columbia-Suicide Severity Rating Scale (C-SSRS).

    Change from baseline to 6 months, 6 months to 9 months, and baseline to 9 months.

  • Suicidal Events (SE)

    SE is defined as yes or no to any suicide attempt plus any ER visits due to suicidal ideation, and suicidal threats based on patient's own report and medical record, or by information gathered from the Child and Adolescent Services Assessment (CASA).

    Change from baseline to 6 months, 6 months to 9 months, and baseline to 9 months.

  • Depressive symptoms by self-report

    Level of depressive symptomatology using the Children Depression Inventory 2 (CDI-2). The CDI uses 27 items with a 4-point Likert type scale, the minimum score is 0 and the maximum 56. It evaluates symptoms such as depressive mood, hedonic capacity, vegetative sign, self-evaluation, and interpersonal behaviors. A higher score means higher level of depressive symptoms.

    Change from baseline to 6 months and baseline to 9 months.

  • Depressive symptoms by clinical interview

    Depressive symptoms using the Children's Depression Rating Scale-Revised (CDRS-R). The CDRS-R is a 17-item interview assessment of depressive symptoms for school aged children and adolescents, with item rating between 1 (no difficulties) to 5 or 7 (clinically significant difficulties). The minimum raw score is 17 and the maximum 113. A higher score means higher level of depressive symptoms. It has been proposed that a score of ≥40 indicates depressive symptomatology comparable to a diagnosis of depression, whereas a score ≤28 was often used as indicative of remission within trials.

    Change from baseline to 6 months and baseline to 9 months.

Study Arms (2)

SCBT-SB (Only)

ACTIVE COMPARATOR

A culturally centered CBT treatment protocol called Socio-Cognitive Behavioral Therapy for Suicidal Behavior (SCBT-SB)

Behavioral: Socio-Cognitive Behavioral Therapy for Suicidal Behavior (SCBT-SB)

New Clinical Model: SCBT-SB + Community Health Worker

EXPERIMENTAL

SCBT-SB treatment with the additional support of a community health worker (CHW)

Behavioral: SCBT-SB + CHW

Interventions

SCBT-SB is a manualized psychosocial treatment protocol developed specifically with and for L/H youth with suicidal ideation and behaviors. Clinician, adolescents, and caregivers' manuals are available in both Spanish and English. SCBT-SB protocol's main conceptual framework and strategies are informed by Cognitive Behavioral Therapy concepts, psychoeducation, and adolescent parenting strategies. The intervention involves individual, caregivers, and family sessions. SCBT-SB, while maintaining the basic principles of CBT, was further developed to include developmental (e.g., identity), and cultural elements of L/H families (e.g., family communication, language). The protocol has two main phases. Phase 1, the Crisis Module, includes nine standard core sessions, and Phase 2, which proposes a flexible number of sessions, focused on the delivery of interchangeable coping skills modules and the acquisition of skills that reduce STB.

SCBT-SB (Only)
SCBT-SB + CHWBEHAVIORAL

The New Clinical Model consist of one clinician delivering the SCBT-SB and one CHW per each family. The assigned clinician \& CHW will meet at the beginning of treatment to discuss their assigned case and will have follow-up meetings as needed and at a minimum, once monthly. CHWs will support family engagement in treatment. CHWs will assess each family's social needs and concerns about treatment. The CHW intervention will 1) Assess social determinants of mental health; 2) Provide referrals and serve as a bridge to other community resources; 3) Provide psychoeducation on mental health and services to decrease stigma; and 4) Follow-up and provide support on recommended actions.

New Clinical Model: SCBT-SB + Community Health Worker

Eligibility Criteria

Age12 Years - 18 Years
Sexall
Healthy VolunteersNo
Age GroupsChild (0-17), Adult (18-64)

You may qualify if:

  • Latinx, defined as have been born in a Latin country or having at least one biological parent, grandparent or an ancestor that was born in a Latin country
  • Severe Suicidal Ideation (SI), defined as one of the following:
  • SIQ-JR \> 22 or endorsing any critical items (2, 3, 4, 7, 8, 9) with at least "about 1x/month"
  • CDI-II \> 15 and endorsing "I think about killing myself but would not do it" OR "I think about killing myself."
  • PHQ-9 \> 10 \& endorsing the item "Thoughts that you would be better off dead, or of hurting yourself in some way" with a frequency of "several days" or greater or endorsing the item "Has there been a time in the past month when you have had serious thoughts about ending your life?
  • Suicidal crisis within the past 12 months
  • Caregivers and adolescents fluent in Spanish or English language and legal guardian willing to participate

You may not qualify if:

  • Participants will be referred to a different treatment program if their main clinical complaint is any of the following:
  • Behavioral (e.g., conduct disorder, or substance use disorder)
  • An eating disorder
  • Obsessive-compulsive disorder
  • A developmental issue (e.g., speech, occupational, families looking for assessments, treatment for autism) or a significant cognitive delay that may require specialized treatment adjustments.

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Bradley Hasbro Children's Research Center

Providence, Rhode Island, 02903, United States

RECRUITING

Related Publications (3)

  • Duarte-Velez Y, Torres-Davila P, Spirito A, Polanco N, Bernal G. Development of a treatment protocol for Puerto Rican adolescents with suicidal behaviors. Psychotherapy (Chic). 2016 Mar;53(1):45-56. doi: 10.1037/pst0000044.

    PMID: 26928136BACKGROUND
  • Jimenez-Colon G, Duarte-Velez Y. Raising Children in Different Cultures: Working with Latinx Youth with Suicidal Behaviors and Their Families. R I Med J (2013). 2022 May 2;105(4):31-35.

    PMID: 35476733BACKGROUND
  • Duarte-Velez Y, Jimenez-Colon G, Jones RN, Spirito A. Socio-Cognitive Behavioral Therapy for Latinx Adolescent with Suicidal Behaviors: A Pilot Randomized Trial. Child Psychiatry Hum Dev. 2024 Jun;55(3):754-767. doi: 10.1007/s10578-022-01439-z. Epub 2022 Oct 1.

    PMID: 36183051BACKGROUND

MeSH Terms

Conditions

DepressionSuicidal IdeationSuicide, Attempted

Condition Hierarchy (Ancestors)

Behavioral SymptomsBehaviorSuicideSelf-Injurious Behavior

Study Officials

  • Yovanska Duarte-Velez, PhD

    Brown University Health

    PRINCIPAL INVESTIGATOR

Central Study Contacts

Yovanska Duarte-Velez, PhD

CONTACT

Gisela Jimenez-Colon, PhD

CONTACT

Study Design

Study Type
interventional
Phase
not applicable
Allocation
RANDOMIZED
Masking
DOUBLE
Who Masked
INVESTIGATOR, OUTCOMES ASSESSOR
Purpose
TREATMENT
Intervention Model
PARALLEL
Sponsor Type
OTHER
Responsible Party
SPONSOR

Study Record Dates

First Submitted

March 17, 2025

First Posted

March 19, 2025

Study Start

March 28, 2024

Primary Completion (Estimated)

January 1, 2027

Study Completion (Estimated)

January 1, 2027

Last Updated

March 19, 2025

Record last verified: 2025-03

Data Sharing

IPD Sharing
Will share

Basic demographics and outcome measures will be uploaded to the NIMH Data Archive with a data dictionary.

Shared Documents
CSR
Time Frame
Data will be available starting 6 months after main study results publication.
Access Criteria
Researchers with access to the NIMH Data Archive will have access to the uploaded data. Data will also be made available to other researchers by request through a Data Sharing Agreement between institutions and as per NIH data sharing guidelines. The PI will also consult to anyone interested in replicating the intervention and study.

Locations