Cord Blood Preptin Levels in Infants

NCT06880003 | Completed

• 1 other identifier: KSH_MB_2025_1
• Study Type: interventional
• Target: 72
• Locations: 1 country
• Sites: 1

Brief Summary

In this study, cord blood preptin levels in infants with high or low birth weight will be compared to those in infants with normal birth weight. Our aim is to determine whether there is a relationship between birth weight and preptin levels. Additionally, we plan to compare the cord blood preptin levels of infants of diabetic mothers with those of normal birth weight infants.

Conditions

Newborn Morbidity; Newborn Complication

Keywords

NEWBORN; preptin; UMBİLİCAL CORD BLOOD

Outcome Measures

Primary Outcomes (1)

• serum preptin level

  The primary outcome variable is the comparison of serum preptin levels between large-for-gestational-age infants and infants of diabetic mothers with those of normal birth weight infants.The other variable is the comparison of serum preptin levels in small-for-gestational-age infants based on gestational age.

  postnatal 5 minutes

Study Arms (4)

Appropriate for gestational age

EXPERIMENTAL

During delivery, blood samples will be collected from the umbilical cord of pregnant women who agree to participate in the study.

Other: During delivery, blood samples will be collected from the umbilical cord

small for gestational age

EXPERIMENTAL

During delivery, blood samples will be collected from the umbilical cord of pregnant women who agree to participate in the study.

Other: During delivery, blood samples will be collected from the umbilical cord

large for gestational age

EXPERIMENTAL

During delivery, blood samples will be collected from the umbilical cord of pregnant women who agree to participate in the study.

Other: During delivery, blood samples will be collected from the umbilical cord

Baby of mother diagnosed with GDM

EXPERIMENTAL

During delivery, blood samples will be collected from the umbilical cord of pregnant women who agree to participate in the study.

Other: During delivery, blood samples will be collected from the umbilical cord

Interventions

During delivery, blood samples will be collected from the umbilical cord OTHER

During delivery, blood samples will be collected from the umbilical cord of pregnant women who agree to participate in the study.

Appropriate for gestational age; Baby of mother diagnosed with GDM; large for gestational age; small for gestational age

Eligibility Criteria

• Age: 1 Minute - 5 Minutes
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Child (0-17)

You may qualify if:

• Large-for-Gestational-Age (LGA) Infants
• Appropriate-for-Gestational-Age (AGA) Infants
• Small-for-Gestational-Age (SGA) Infants
• Infants of Diabetic Mothers (IDM)

You may not qualify if:

• Infants with a syndromic appearance or any accompanying disease
• Infants whose families did not provide consent

Sponsors & Collaborators

• Konya City Hospital: lead

Study Sites (1)

Melek Buyukeren

Konya, Karatay, 42020, Turkey (Türkiye)

Location

Related Publications (8)

• Ungureanu MC, Bilha SC, Hogas M, Velicescu C, Leustean L, Teodoriu LC, Preda C. Preptin: A New Bone Metabolic Parameter? Metabolites. 2023 Sep 4;13(9):991. doi: 10.3390/metabo13090991.

  PMID: 37755271 BACKGROUND

• Aydin S. Three new players in energy regulation: preptin, adropin and irisin. Peptides. 2014 Jun;56:94-110. doi: 10.1016/j.peptides.2014.03.021. Epub 2014 Apr 8.

  PMID: 24721335 BACKGROUND

• Buchanan CM, Phillips AR, Cooper GJ. Preptin derived from proinsulin-like growth factor II (proIGF-II) is secreted from pancreatic islet beta-cells and enhances insulin secretion. Biochem J. 2001 Dec 1;360(Pt 2):431-9. doi: 10.1042/0264-6021:3600431.

  PMID: 11716772 BACKGROUND

• Cheng KC, Li YX, Asakawa A, Ushikai M, Kato I, Sato Y, Cheng JT, Inui A. Characterization of preptin-induced insulin secretion in pancreatic beta-cells. J Endocrinol. 2012 Oct;215(1):43-9. doi: 10.1530/JOE-12-0176. Epub 2012 Jul 11.

  PMID: 22787110 BACKGROUND

• Yang G, Li L, Chen W, Liu H, Boden G, Li K. Circulating preptin levels in normal, impaired glucose tolerance, and type 2 diabetic subjects. Ann Med. 2009;41(1):52-6. doi: 10.1080/07853890802244142.

  PMID: 18618352 BACKGROUND

• Celik O, Celik N, Hascalik S, Sahin I, Aydin S, Ozerol E. An appraisal of serum preptin levels in PCOS. Fertil Steril. 2011 Jan;95(1):314-6. doi: 10.1016/j.fertnstert.2010.08.058.

  PMID: 20883990 BACKGROUND

• Aslan M, Celik O, Karsavuran N, Celik N, Dogan DG, Botan E, Kafkasli A. Maternal serum and cord blood preptin levels in gestational diabetes mellitus. J Perinatol. 2011 May;31(5):350-5. doi: 10.1038/jp.2010.125. Epub 2010 Dec 16.

  PMID: 21164426 BACKGROUND

• Kirac UI, Demir E, Ozkan H, Sahtiyanci B, Uzun H, Ekinci I, Buyukkaba M, Durmus S, Akarsu M, Gelisgen R, Tabak O. Maternal serum preptin levels in the pathogenesis and diagnosis of Gestational diabetes mellitus. J Med Biochem. 2023 Mar 15;42(2):311-317. doi: 10.5937/jomb0-36287.

  PMID: 36987416 BACKGROUND

Study Officials

• MELEK BUYUKEREN

  Konya City Hospital

  PRINCIPAL INVESTIGATOR

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NON RANDOMIZED
• Masking: NONE
• Purpose: DIAGNOSTIC
• Intervention Model: PARALLEL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Associate Professor

Model Details: Between March 2025 and November 2025, mothers of infants born at Konya City Hospital who have either high or low birth weight for their gestational age or are infants of diabetic mothers (study group) will be informed about the study. If they agree to participate, written informed consent will be obtained. Similarly, during the same period, mothers of infants estimated to have normal birth weight for their gestational age (control group) will be informed about the study, and written informed consent will be obtained if they agree to participate. Blood samples collected from the umbilical cord at birth will be processed in the biochemistry laboratory, and the serum will be separated and stored at -80°C. After reaching the target sample size, preptin levels will be analyzed. The cost of the kits used for the preptin test will be covered by the researchers.

Study Record Dates

• First Submitted: March 11, 2025
• First Posted: March 17, 2025
• Study Start: March 10, 2025
• Primary Completion: November 1, 2025
• Study Completion: November 1, 2025
• Last Updated: March 27, 2026

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

TU (1)