Assessment of Prognosis and Myocardial Reperfusion in Patients with ST-segment-elevation Myocardial Infarction (STEMI) According to Coronary Atherosclerotic Burden.

NCT06876974 | Not Yet Recruiting

• 1 other identifier: 2025PI034
• Study Type: observational
• Target: 2,200
• Locations: 0 countries
• Sites: N/A

Brief Summary

In the current literature, it has been widely demonstrated that the extend of coronary atherosclerotic burden is associated with adverse long-term outcomes. Little is known about the impact of atheroma burden and either myocardial reperfusion and short-term outcomes after ST-segment elevation myocardial infarction (STEMI). Several angiographic scores have been used to measure the extend and severity of coronary atheroma. The SYNTAX score and the Gensini score have been shown to be independent predictors of cardiovascular events and mortality in stable coronary artery disease as well as in myocardial infarction. This research therefore aims to assess the impact of overall coronary atherosclerotic burden, measured by two angiographic scores (SYNTAX score and Gensini score), both before and after primary percutaneous angioplasty, in patients with STEMI according to different clinical subgroups.

Conditions

STEMI - ST Elevation Myocardial Infarction (MI)

Outcome Measures

Primary Outcomes (2)

• All-cause mortality

  all-cause mortality at 45 days, 1 year and 2 years

  2 years

• Recurrent acute coronary syndrome

  Recurrent acute coronary syndrome at 1-year

  1 year

Secondary Outcomes (2)

• All-cause mortality in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock

  2 years

• Recurrent acute coronary syndrome in patients with STEMI related to out-of-hospital cardiac arrest or cardiogenic shock

  1 year

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

Patients presenting with STEMI and treated with primary PCI (pPCI) at the University Hospital of Nancy between 2003 and 2023. STEMI was defined as follows: 1. continuous chest pain lasting at least 20 min 2. ST-segment elevation ≥1 mm in ≥2 contiguous leads on a 12-lead electrocardiogram or left bundle branch block and (3) treatment within 24 h of pain onset.

You may qualify if:

• \- patients presenting with STEMI and treated with primary PCI (pPCI) at the University Hospital of Nancy between 2003 and 2023.

You may not qualify if:

• \- patients with missing or incomplete coronary angiogram.

Sponsors & Collaborators

• Central Hospital, Nancy, France: lead

MeSH Terms

Conditions

ST Elevation Myocardial Infarction

Condition Hierarchy (Ancestors)

Myocardial Infarction; Myocardial Ischemia; Heart Diseases; Cardiovascular Diseases; Vascular Diseases; Infarction; Ischemia; Pathologic Processes; Pathological Conditions, Signs and Symptoms; Necrosis

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: February 21, 2025
• First Posted: March 14, 2025
• Study Start: March 1, 2025
• Primary Completion: March 1, 2025
• Study Completion: March 1, 2025
• Last Updated: March 14, 2025

Record last verified: 2025-03