SPIR
EFFECTS OF COMPLEXITY AND MULTIMORBIDITY ON CLINICAL OUTCOMES IN HOSPITALIZED INTERNAL MEDICINE PATIENTS
Sponsor study identifier
observational
2,326
1 country
21
Study Start
June 24, 2024
Actual (reported)Primary Completion
September 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Study Completion
September 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
The goal of this observational study is to evaluate the association between complexity and multiple illnesses of adult hospitalized internal medicine patient and mortality. Each enrolled participant will undergo a 12-month follow-up. The study foresees the enrollment of 2326 participants.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
September 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
June 24, 2024
Actual (reported)February 25, 2025
Actual (reported)March 12, 2025
Actual (reported)September 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
September 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Correlation between clinical complexity/multimorbidity and mortality
Correlation between clinical complexity/multimorbidity of the hospitalized internal medicine patient, defined by the Cumulative Illness Rating Scale (CIRS), and mortality. Cumulative Illness Rating Scale: severity index (minimum value is 1, maximum value is 5), comorbidity index (minimum value is 0, maximum value is 13). Higher scores mean worse outcome.
12 months
Correlation between pre-existing factors at hospitalization and clinical outcomes
12 months
Adult hospitalized internal medicine patient
ASST Lariana - Ospedale Sant'Anna di San Fermo della Battaglia - UOC Medicina Generale
San Fermo della Battaglia, CO, 22042, Italy
ASP di Catanzato - Presidio Ospedaliero "Giovanni Paolo II" di Lamezia Terme
Catanzaro, CZ, 88056, Italy
First Submitted
February 25, 2025
First Posted
March 12, 2025
Study Start
June 24, 2024
Actual (reported)Primary Completion
September 2029
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Contact the study team to confirm eligibility.
AOU "Dulbecco" di Catanzaro - Presidio Ospedaliero di Germaneto - UOC Geriatria
Catanzaro, CZ, 88100, Italy
AOU Careggi - SOD Medicina Interna 4
Florence, FI, 50134, Italy
AOU Policlinico G. Martino - UOC Medicina Interna
Messina, ME, 98124, Italy
ASST Grande Ospedale Metropolitano Niguarda - UOC Medicina Interna - Alta Complessità Medica
Milan, MI, 20162, Italy
Fondazione Policlinico Universitario Tor Vergata - UOC Medicina Interna Centro Medico per l'Obesità
Roma, RM, 00133, Italy
AOU Policlinico Umberto I - UOC Medicina Interna e Nutrizione Clinica
Roma, RM, 00161, Italy
IRCCS Ospedale San Raffaele - UO di Medicina Generale ad Indirizzo Specialistico e della Continuità Assistenziale
Roma, RM, 00163, Italy
ASL 5 - Presidio Ospedaliero San Bartolomeo di Sarzana - UO di Clinica Medica Interna e Immunologia
Sarzana, SP, 19038, Italy
ASST Sette Laghi - Ospedale di Circolo di Varese
Varese, VA, 21100, Italy
AOU Policlinico di Bari - UO Medicina Interna
Bari, 70124, Italy
AOU Policlinico S. Orsola-Malpighi - UO Medicina interna, malattie epatobiliari e immunoallergologiche
Bologna, 40138, Italy
ASST degli Spedali Civili di Brescia - UO di Medicina Generale 2
Brescia, 25121, Italy
Ospedale Santa Maria Annunziata, Bagno a Ripoli - UOC di Medicina 1
Florence, 50012, Italy
ASST Fatebenefratelli Sacco - Ospedale Luigi Sacco - SC di Medicina Interna
Milan, 20157, Italy
AOU Policlinico di Modena - UOC Medicina Interna
Modena, 44124, Italy
AOU Federico II di Napoli - UOC Medicina Interna ad indirizzo metabolico e riabilitativo
Naples, 80131, Italy
AOU Maggiore della Carità - UOC di Medicina Interna 1
Novara, 28100, Italy
Policlinico Universitario Campus Bio-Medico di Roma - UOC di Medicina Interna
Roma, 00128, Italy
AOU Sant'Andrea - UOC di Medicina Interna
Roma, 00189, Italy
Study Completion
September 2030
EstimatedPlanned date reported by the registry; this milestone is not confirmed as achieved.
Last Updated
October 27, 2026
Record last verified: 2026-10
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