Maternal Iron Deficiency and/or Iron Deficiency Anemia to Neonatal Hemoglobin Concentration and Iron Stores

NCT06871917 | Not Yet Recruiting DMC

• 1 other identifier: FAMAssiutU
• Study Type: observational
• Target: 370
• Locations: 1 country
• Sites: 1

Brief Summary

study the relationship between maternal iron deficiency (ID) and/or iron deficiency anemia (IDA) to neonatal hemoglobin concentration and iron stores at birth

Conditions

Relation, Mother-Child

Keywords

anemia iron deficiency iron stores

Outcome Measures

Primary Outcomes (1)

• Evaluation the effect of maternal iron deficiency (ID) and/or iron deficiency anemia (IDA) to fetal haemoglobin concentration and fetal iron stores.

  evaluation the correlation between ID and IDA in maternal and neonatal samples

  2 years

Secondary Outcomes (2)

• -Prevalence of maternal iron deficiency and/or iron deficiency anemia at birth in our community.

  2 years

• -Effect of maternal iron deficiency and/or iron deficiency anemia on early neonatal outcome .

  2 years

Eligibility Criteria

• Age: 21 Years - 40 Years
• Sex: all
• Healthy Volunteers: Yes
• Age Groups: Adult (18-64)
• Sampling Method: Probability Sample

Study Population

The study will include all pregnant women meet the inclusion criteria and their infant pairs at the time of delivery.

You may qualify if:

• All pregnant women and their infant pairs who have given consent to participate.
• Mothers Age: 21-40 years' old.
• Term infants (37-42 weeks of gestation) with birth weight ≥2500 g born to mothers who had an uncomplicated normal singleton vaginal delivery or caesarian section delivery was included.

You may not qualify if:

• Mothers with a history of antepartum hemorrhage, pre-mature labor pain, high-risk pregnancy (eg. history of trauma and severe infection during pregnancy), severe hyperemesis, pre-eclampsia severe anemia requiring blood transfusion, and any chronic medical illnesses as: gestational diabetes, hypertension, hypothyroidism, epilepsy, liver disease, renal disease cardiorespiratory disease, immunodeficiency syndrome, and hematological (other causes of anemia)
• infants who suspected with congenital and/or chromosomal anomalies and pathological jaundice, also multiple pregnancy was excluded from the study.
• Mothers withdrew from given a written consent will be excluded from the study.

Sponsors & Collaborators

• Assiut University: lead

Study Sites (1)

Naglaa Ali Ali

Asyut, Egypt

Location

Related Publications (7)

• Krafft A, Huch R, Breymann C. Impact of parturition on iron status in nonanaemic iron deficiency. Eur J Clin Invest. 2003 Oct;33(10):919-23. doi: 10.1046/j.1365-2362.2003.01244.x.

  PMID: 14511365 BACKGROUND

• Bentley DP. Iron metabolism and anaemia in pregnancy. Clin Haematol. 1985 Oct;14(3):613-28.

  PMID: 3907911 BACKGROUND

• Mei Z, Cogswell ME, Looker AC, Pfeiffer CM, Cusick SE, Lacher DA, Grummer-Strawn LM. Assessment of iron status in US pregnant women from the National Health and Nutrition Examination Survey (NHANES), 1999-2006. Am J Clin Nutr. 2011 Jun;93(6):1312-20. doi: 10.3945/ajcn.110.007195. Epub 2011 Mar 23.

  PMID: 21430118 BACKGROUND

• Scholl TO. Iron status during pregnancy: setting the stage for mother and infant. Am J Clin Nutr. 2005 May;81(5):1218S-1222S. doi: 10.1093/ajcn/81.5.1218.

  PMID: 15883455 BACKGROUND

• Lozoff B. Iron deficiency and child development. Food Nutr Bull. 2007 Dec;28(4 Suppl):S560-71. doi: 10.1177/15648265070284S409.

  PMID: 18297894 BACKGROUND

• Delaney KM, Guillet R, Fleming RE, Ru Y, Pressman EK, Vermeylen F, Nemeth E, O'Brien KO. Umbilical Cord Serum Ferritin Concentration is Inversely Associated with Umbilical Cord Hemoglobin in Neonates Born to Adolescents Carrying Singletons and Women Carrying Multiples. J Nutr. 2019 Mar 1;149(3):406-415. doi: 10.1093/jn/nxy286.

  PMID: 30770543 BACKGROUND

• Bernhardt GV, Jhancy M, Shivappa P, Bernhardt K, Pinto JRT. Relationship between maternal and cord blood iron status in women and their new born pairs. Vol. 14, Biomedical and Pharmacology Journal. 2021. p. 317-22.

  BACKGROUND

Study Officials

• Dalia G. Mahran, prof

  prof of public health and community medicine, Faculty of medicine, Assuit university

  STUDY DIRECTOR

Central Study Contacts

naglaa A ali

CONTACT

01014616671; naglaaali11995@gmail.com

Study Design

• Study Type: observational
• Observational Model: OTHER
• Time Perspective: CROSS SECTIONAL
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: assistant lecturer at family medicine department AUH

Study Record Dates

• First Submitted: March 7, 2025
• First Posted: March 12, 2025
• Study Start: June 8, 2025
• Primary Completion: April 1, 2026
• Study Completion (Estimated): April 1, 2027
• Last Updated: May 23, 2025

Record last verified: 2025-05

Locations

EG (1)