NCT06870552

Brief Summary

This study examines the time course of activation of the left anterior temporal lobe (ATL) during lexical processing using Transcranial Magnetic Stimulation (TMS).

Trial Health

57
Monitor

Trial Health Score

Automated assessment based on enrollment pace, timeline, and geographic reach

Trial has exceeded expected completion date
Enrollment
36

participants targeted

Target at P25-P50 for not_applicable

Timeline
Completed

Started Apr 2024

Geographic Reach
1 country

1 active site

Status
recruiting

Health score is calculated from publicly available data and should be used for screening purposes only.

Trial Relationships

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Study Timeline

Key milestones and dates

Study Start

First participant enrolled

April 23, 2024

Completed
5 months until next milestone

First Submitted

Initial submission to the registry

September 23, 2024

Completed
6 months until next milestone

First Posted

Study publicly available on registry

March 11, 2025

Completed
5 months until next milestone

Primary Completion

Last participant's last visit for primary outcome

August 1, 2025

Completed
1 month until next milestone

Study Completion

Last participant's last visit for all outcomes

September 1, 2025

Completed
Last Updated

March 11, 2025

Status Verified

March 1, 2025

Enrollment Period

1.3 years

First QC Date

September 23, 2024

Last Update Submit

March 5, 2025

Conditions

Lexical Access in Neurotypicals

Keywords

semantic processingtime courselexical accessanterior temporal lobe

Outcome Measures

Primary Outcomes (1)

  • Mean reaction time changes in lexical decision from TMS at 150 ms

    An interaction between time point (-100, 150) and task (lexical decision, number judgment) RT at the group level (one tailed). (LD\_150 - LD\_-100) - (NJ\_150 - NJ\_-100).

    Through study completion, an average of 1 year.

Secondary Outcomes (1)

  • Mean reaction time changes in semantic decision from TMS at 150 ms

    Through study completion, an average of 1 year.

Other Outcomes (6)

  • Mean reaction time changes in lexical decision from TMS

    Through study completion, an average of 1 year.

  • Mean reaction time changes in semantic decision from TMS

    Through study completion, an average of 1 year.

  • Mean reaction time changes in lexical decision from TMS at 400 ms

    Through study completion, an average of 1 year.

  • +3 more other outcomes

Study Arms (1)

TMS

EXPERIMENTAL
Device: Single-pulse TMS

Interventions

Single-pulse TMSDEVICE

A single pulse TMS is delivered at different time points when processing words or numbers.

TMS

Eligibility Criteria

Age18 Years - 40 Years
Sexall
Healthy VolunteersYes
Age GroupsAdult (18-64)

You may qualify if:

  • Participants must be within the ages of 18 to 40
  • Native speakers of English

You may not qualify if:

  • Potential participants with a clinically reported history of dementia, alcohol abuse, psychiatric or neurological disorders, traumatic brain injury, or extensive vision or hearing problems that prevents them from performing the tasks
  • Contraindication to TMS, determined by a standard TMS screening form
  • Contraindication to MRI, determined by a standard MRI screening form
  • Left handed participants

Contact the study team to confirm eligibility.

Sponsors & Collaborators

Study Sites (1)

Prisma Health Richland

Columbia, South Carolina, 29208, United States

RECRUITING

Central Study Contacts

Rutvik H Desai, PhD

CONTACT

8032617149rutvik@sc.edu

Study Design

Study Type
interventional
Phase
not applicable
Allocation
NA
Masking
NONE
Purpose
BASIC SCIENCE
Intervention Model
SINGLE GROUP
Sponsor Type
OTHER
Responsible Party
PRINCIPAL INVESTIGATOR
PI Title
Professor

Study Record Dates

First Submitted

September 23, 2024

First Posted

March 11, 2025

Study Start

April 23, 2024

Primary Completion

August 1, 2025

Study Completion

September 1, 2025

Last Updated

March 11, 2025

Record last verified: 2025-03

Locations

US(1)