A Comparative Study of Tumor Specific Mesocolic Excision and Complete Mesocolic Excision for Right Sided Colon Cancer : Asian Multicenter Retrospective Study

NCT06865586 | Completed

• 1 other identifier: SMART core
• Study Type: observational
• Target: 3,326
• Locations: 1 country
• Sites: 1

Brief Summary

The goal of this observational study is to determine the optimal surgical strategy based on oncologic outcomes in patients with stage I-III right-sided colon cancer who underwent curative right hemicolectomy. The main question it aims to answer is: Is there a significant difference in 5-year recurrence-free survival (RFS) between patients treated with Complete Mesocolic Excision (CME) and those treated with tumor specific mesocolic excision (TSME)? Participants will include patients who underwent curative right hemicolectomy for right-sided colon cancer between 2015 and 2020 at eight institutions. They will be categorized into two groups based on the surgical technique received-CME group and TSME group-and evaluated for primary and secondary endpoints of 5-year recurrence-free survival (RFS) and overall survival (OS), respectively.

Conditions

Colon Cancer; Lymph Node Dissection; Laparoscopic Colon Surgery; Robotic Surgical Procedure

Keywords

colon cancer; right hemicolectomy; complete mesocolic excision; lymph node dissection; microinvasive surgery

Outcome Measures

Primary Outcomes (1)

• 5 year Recurrence free survival

  Recurrence-Free Survival (RFS) between patients who underwent TSME and CME procedures from 2015 to 2020

  Outcome measures will be assessed at 5 years post-surgery.

Secondary Outcomes (1)

• Overall survival

  Outcome measures will be assessed at 5 years post-surgery.

Study Arms (2)

Patients who underwent laparoscopic or robotic right hemicolectomy with CME from 2015 to 2020

Patients who underwent laparoscopic or robotic right hemicolectomy with Complete mesocolic excision from 2015 to 2020 in 8 centers

Patients who underwent with tumor specific mesocolic exicision from 2015 to 2020

Patients who underwent laparoscopic or robotic right hemicolectomy with tumor specific mesocolic exicision from 2015 to 2020 in 8 centers

Eligibility Criteria

• Sex: all
• Healthy Volunteers: No
• Age Groups: Child (0-17), Adult (18-64), Older Adult (65+)
• Sampling Method: Non-Probability Sample

Study Population

This study included patients who underwent laparoscopic or robotic right hemicolectomy from 2015 to 2020 at 8 instituions : Asan Medical Center, Korea University Anam Hospital, Severance Hospital, Kyungpook National University Chilgok Hospital, Chinese University of Hong Kong, North District Hospital, Pamela Youde Nethersole Eastern Hospital, and China Medical University Hospital.

You may qualify if:

• Patients who underwent laparoscopic or robotic right hemicolectomy from 2015 to 2020
• Patients who received curative right hemicolectomy with lymphadenectomy

You may not qualify if:

• Familial adenomatous polyposis (FAP)
• Hereditary non-polyposis colon cancer (HNPCC)
• Patients with inflammatory bowel disease
• Patients with synchronous malignancies in other organs
• Patients with non-adenocarcinoma histology of colon cancer
• Patients with follow-up duration of less than 3 months

Sponsors & Collaborators

• Asan Medical Center: lead
• Korea University Anam Hospital: collaborator
• Kyungpook National University Chilgok Hospital: collaborator
• Severance Hospital: collaborator
• Chinese University of Hong Kong: collaborator
• Pamela Youde Nethersole Eastern Hospital: collaborator
• North District Hospital: collaborator
• China Medical University Hospital: collaborator

Study Sites (1)

Asan Medical Center

Seoul, Songpa, 05505, South Korea

Location

MeSH Terms

Conditions

Colonic Neoplasms

Condition Hierarchy (Ancestors)

Colorectal Neoplasms; Intestinal Neoplasms; Gastrointestinal Neoplasms; Digestive System Neoplasms; Neoplasms by Site; Neoplasms; Digestive System Diseases; Gastrointestinal Diseases; Colonic Diseases; Intestinal Diseases

Study Design

• Study Type: observational
• Observational Model: COHORT
• Time Perspective: RETROSPECTIVE
• Sponsor Type: OTHER
• Responsible Party: PRINCIPAL INVESTIGATOR
• PI Title: Professor

Study Record Dates

• First Submitted: March 6, 2025
• First Posted: March 10, 2025
• Study Start: January 1, 2015
• Primary Completion: December 31, 2020
• Study Completion: January 15, 2025
• Last Updated: March 10, 2025

Record last verified: 2025-03

Data Sharing

• IPD Sharing: Will not share

Locations

KR (1)