NCT06865300|CompletedDMC
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Sponsor study identifier
interventional
210
1 country
2
Study Start
July 1, 2023
Actual (reported)Primary Completion
October 31, 2023
Actual (reported)Study Completion
December 31, 2023
Actual (reported)One of the medications administered to patients in general anesthesia practice is rocuronium, which causes pain during intravenous administration. It is known that a drug containing lidocaine as the active ingredient can reduce the pain caused by rocuronium in different doses. The effective dose of lidocaine remains a topic of debate. In our study, we aimed to investigate the efficacy of two different doses of lidocaine. No adverse effects are expected from this medication.
Registry-reported information. Elapsed time and enrollment totals alone do not measure study progress or recruitment pace.
December 31, 2023
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Dates and qualifiers reported by the registry. Estimated dates do not confirm that a milestone has occurred.
July 1, 2023
Actual (reported)October 31, 2023
Actual (reported)December 31, 2023
Actual (reported)February 9, 2025
Actual (reported)March 7, 2025
Actual (reported)Visual analog score after the injection
We described Visual analog scale to the patient before the day of surgery. On the visual analog scale, a score of 10 is the worst pain in life, while a score of 0 is no pain. The patient is asked to give a score to his pain caused by rocuronium injection and the score is recorded.
From enrollment to the end of injection at 5 minutes.
Changes on heart rate
Hemodynamic parameters were recorded 5 minutes intervals. Adverse effects of the drug were observed during 5 minutes after the injection.
Changes on noninvasive blood pressure
Hemodynamic parameters were recorded 5 minutes intervals. Adverse effects of the drug were observed during 5 minutes after the injection.
Changes on oxygen saturation
Hemodynamic parameters were recorded 5 minutes intervals.
Adverse effects
Adverse effects of the drug were observed during 5 minutes after the injection.
We injected serum physiologic that contains no drug before injection of rocuronium and recorded pain score.
We injected 40 mg lidocain for the prevention of injection pain caused by rocuronium. We injected 0.06 mg/kg rocurunium and recorded pain by using visual analog scale.
We injected 1 mg/kg lidocain for the prevention of injection pain caused by rocuronium. We injected 0.06 mg/kg rocurunium and recorded pain score by using visual analog scale.
We injected 40 mg lidocain before rocuronium injection. Then we recorded pain score by using visual analog scale.
We injected 1 mg/kg lidocain before rocuronium injection. Then we recorded pain score by using visual analog scale.
Giresun University
Giresun, Turkey, Turkey (Türkiye)
Giresun Training and Research Hospital
Giresun, Turkey (Türkiye)
Singh M, Chauhan H, Rath GP, Prabhakar H, Bithal PK, Dash HH. Effect of narcotic pretreatment on pain after rocuronium injection: a randomized, double-blind controlled comparison with lidocaine. J Anesth. 2007;21(4):510-2. doi: 10.1007/s00540-007-0560-8. Epub 2007 Nov 1.
Chiarella AB, Jolly DT, Huston CM, Clanachan AS. Comparison of four strategies to reduce the pain associated with intravenous administration of rocuronium. Br J Anaesth. 2003 Mar;90(3):377-9. doi: 10.1093/bja/aeg054.
Azime Bulut
Giresun University
210 participants (actual enrollment reported by the registry).
First Submitted
February 9, 2025
First Posted
March 7, 2025
Study Start
July 1, 2023
Actual (reported)Effect of Saccharomyces Boulardii on Indirect Hyperbilirubinemia and Phototherapy Duration in Very Low Birth Weight Infants
We injected serum physiologic before rocuronium injection. Then we recorded pain score by using visual analog scale.
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Ergil J, Kavak Akelma F, Ozkan D, Bumin Aydin G, Gurel A, Akinci M. Effects of pretreatment with esmolol and lidocaine on injection pain and rocuronium-induced withdrawal response. Turk J Med Sci. 2015;45(4):959-63. doi: 10.3906/sag-1311-79.
Ahmad N, Choy CY, Aris EA, Balan S. Preventing the withdrawal response associated with rocuronium injection: a comparison of fentanyl with lidocaine. Anesth Analg. 2005 Apr;100(4):987-990. doi: 10.1213/01.ANE.0000147790.76114.3A.
Cheong KF, Wong WH. Pain on injection of rocuronium: influence of two doses of lidocaine pretreatment. Br J Anaesth. 2000 Jan;84(1):106-7. doi: 10.1093/oxfordjournals.bja.a013364.
Primary Completion
October 31, 2023
Actual (reported)Study Completion
December 31, 2023
Actual (reported)Last Updated
March 7, 2025
Record last verified: 2025-03
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