Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases

NCT06859619 | Not Yet Recruiting

• 1 other identifier: RECHMPL24_0384
• Study Type: interventional
• Target: 183
• Locations: 1 country
• Sites: 1

Brief Summary

Zoonoses and arboviroses refer to a group of diseases transmitted from animals to humans, either directly or indirectly (via mosquitoes, ticks or contact with contaminated environments). Most of these diseases are found in certain tropical zones, but global warming and increased international trade are modifying their geographical distribution, with a gradual trend towards temperate regions. A number of these pathogens have already been detected in Occitania, including dengue fever, West Nile, leishmaniasis and Q fever. Given the region's high mosquito population and favorable climatic conditions, other zoonoses have a strong potential to appear in the region, or may already be circulating at a low level. The study focuses on 18 pathogens selected for their potential to emerge and establish themselves in the Occitanie region: Leishmaniasis, Leptospirosis, Brucellosis, Q fever, Rickettsiosis, Tularemia, Psittacosis, Lyme disease, Tick-borne encephalitis, Hantavirus, Hepatitis E virus, Dengue virus, Zika virus, Chikungunya virus, West-Nile virus, Usutu virus, Toscana virus, Crimean-Congo haemorrhagic fever virus. The aim of the study is to find out whether patients have antibodies against these infectious agents, which would indicate that they have been exposed to them in the past, even in the absence of symptoms. Describing the circulation of these pathogens will enable to implement appropriate public health measures to avoid the risk of epidemics (mosquito control, informing professionals, etc.), as well as to assess the risk incurred in the workplace and have this risk recognized by the healthcare system.

Conditions

Leishmaniasis; Leptospirosis; Brucellosis; Q Fever; Rickettsiosis; Tularemia; Psittacosis; Lyme Disease; Tick-borne Encephalitis; Hantaviral Infection Nos; Hepatitis E; Dengue Virus; Zika Virus; Chikungunya Virus Infection; West Nile Virus; Usutu Virus; Toscana Virus; Crimean-Congo Haemorrhagic Fever Virus

Keywords

Leishmaniasis,; Leptospirosis; Brucellosis; Zika virus; Q fever, Rickettsiosis; Lyme disease; Tick-borne encephaliti; Hantavirus; Hepatitis E virus; Dengue virus; Chikungunya virus; West-Nile virus; Usutu virus; Toscana virus; Tularemia; Psittacosis; Crimean-Congo haemorrhagic fever virus; epidemiology

Outcome Measures

Primary Outcomes (18)

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies). Leishmaniasis,

  prevalence (in percentage) of pathogen IgG positivity against : Leishmaniasis,

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Leptospirosis,

  prevalence of pathogen IgG positivity against : Leptospirosis,

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Brucellosis

  prevalence of pathogen IgG positivity against : Brucellosis

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Q fever

  prevalence of pathogen IgG positivity against : Q fever

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Rickettsiosis

  prevalence of pathogen IgG positivity against : Rickettsiosis,

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Tularemia

  prevalence of pathogen IgG positivity against : Tularemia

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Psittacosis

  prevalence of pathogen IgG positivity against : Psittacosis

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Lyme disease,

  prevalence of pathogen IgG positivity against : Lyme disease,

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Tick-borne encephalitis

  prevalence of pathogen IgG positivity against : Tick-borne encephalitis

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Hantavirus

  prevalence of pathogen IgG positivity against : Hantavirus

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies). Hepatitis E virus

  prevalence of pathogen IgG positivity against : Hepatitis E virus

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Dengue virus

  prevalence of pathogen IgG positivity against : Dengue virus

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies). Zika virus

  prevalence of pathogen IgG positivity against : Zika virus

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Chikungunya virus

  prevalence of pathogen IgG positivity against : Chikungunya virus

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies). West-Nile virus,

  prevalence of pathogen IgG positivity against : West-Nile virus,

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies). usutu virus

  prevalence of pathogen IgG positivity against : Usutu virus

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Toscana virus

  prevalence of pathogen IgG positivity against : Toscana virus

  Baseline

• Estimate seroprevalences of the zoonoses in populations exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies).Crimean-Congo haemorrhagic fever virus.

  prevalence of pathogen IgG positivity against : Crimean-Congo haemorrhagic fever virus.

  Baseline

Secondary Outcomes (23)

• Determine the factors associated with seropositivity to these diseases. socio-demographic criteria

  Baseline

• Determine the factors associated with seropositivity to these diseases. travel to endemic areas

  Baseline

• Determine the factors associated with seropositivity to these diseases. occupational exposure

  Baseline

• Determine the factors associated with seropositivity to these diseases. exposure in private activities

  Baseline

• Determine the factors associated with seropositivity to these diseases. use of mosquito protection

  Baseline

Study Arms (1)

City of Montpellier employees working at the Zoo, the Ecolothèque and the Green Spaces Department

EXPERIMENTAL

City of Montpellier employees working at the Zoo, Ecolotheque or green spaces exposed to wildlife by zoo staff and to various vectors (ticks, mosquitoes, sandflies) in the Occitanie region

Other: Peripheral venous blood sample

Interventions

Peripheral venous blood sample OTHER

Peripheral venous blood sampling for IgG serology against leishmaniasis, leptospirosis, brucellosis, Q fever, rickettsiosis, tularemia, psittacosis, Lyme disease, tick-borne encephalitis, hantavirus, hepatitis E virus, dengue virus, Zika virus, Chikungunya virus, West Nile virus, Usutu virus, Toscana virus, Crimean-Congo hemorrhagic fever virus.

City of Montpellier employees working at the Zoo, the Ecolothèque and the Green Spaces Department

Eligibility Criteria

• Age: 18 Years+
• Sex: all
• Healthy Volunteers: No
• Age Groups: Adult (18-64), Older Adult (65+)

You may qualify if:

• Age 18 or over
• Consultant in an infectious diseases department
• Have given written consent to participate in the study
• Working for the City or Metropolis of Montpellier in the Zoo, Espaces Vert or Ecolothèque departments.

You may not qualify if:

• \- Pregnant and breast-feeding women
• Persons benefiting from legal protection measures (guardianship, curatorship, safeguard of justice)
• Participants who are not fluent in French and who do not have a support person capable of reading French.
• Persons unable to express their consent.
• Persons not affiliated to a social security scheme or not benefiting from such a scheme.

Sponsors & Collaborators

• University Hospital, Montpellier: lead
• TransVIHMI UM, IRD UMI233, Inserm U1175: collaborator
• UMR 1058 Pathogenesis & Control of Chronic & Emerging Infections PCCEI: collaborator

Study Sites (1)

University Hospital Of Montpellier

Montpellier, herault, 34295, France

Location

MeSH Terms

Conditions

Leishmaniasis; Leptospirosis; Brucellosis; Q Fever; Rickettsia Infections; Tularemia; Psittacosis; Lyme Disease; Encephalitis, Tick-Borne; Hepatitis E; Zika Virus Infection; Chikungunya Fever; Hantavirus Pulmonary Syndrome

Condition Hierarchy (Ancestors)

Euglenozoa Infections; Protozoan Infections; Parasitic Diseases; Infections; Skin Diseases, Parasitic; Vector Borne Diseases; Skin Diseases, Infectious; Skin Diseases; Skin and Connective Tissue Diseases; Spirochaetales Infections; Gram-Negative Bacterial Infections; Bacterial Infections; Bacterial Infections and Mycoses; Rickettsiaceae Infections; Tick-Borne Diseases; Chlamydophila Infections; Chlamydiaceae Infections; Borrelia Infections; Encephalitis, Arbovirus; Encephalitis, Viral; Central Nervous System Viral Diseases; Central Nervous System Infections; Infectious Encephalitis; Arbovirus Infections; Virus Diseases; RNA Virus Infections; Flavivirus Infections; Flaviviridae Infections; Encephalitis; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Neuroinflammatory Diseases; Hepatitis, Viral, Human; Hepatitis; Liver Diseases; Digestive System Diseases; Mosquito-Borne Diseases; Alphavirus Infections; Togaviridae Infections; Hantavirus Infections; Bunyaviridae Infections; Respiratory Insufficiency; Respiration Disorders; Respiratory Tract Diseases

Study Officials

• CHARLOTTE BOULLE, MD

  University Hospital, Montpellier

  PRINCIPAL INVESTIGATOR

Central Study Contacts

CHARLOTTE BOULLE, MD

CONTACT

04 67 33 52 34; c-boulle@chu-montpellier.fr

Study Design

• Study Type: interventional
• Phase: not applicable
• Allocation: NA
• Masking: NONE
• Purpose: SCREENING
• Intervention Model: SINGLE GROUP
• Sponsor Type: OTHER
• Responsible Party: SPONSOR

Model Details: cross-sectional study with minimal risk and constraints

Study Record Dates

• First Submitted: February 27, 2025
• First Posted: March 5, 2025
• Study Start: March 3, 2025
• Primary Completion: October 3, 2025
• Study Completion: October 3, 2025
• Last Updated: March 5, 2025

Record last verified: 2025-02

Locations

FR (1)